{"id":20573,"date":"2018-04-05T16:50:46","date_gmt":"2018-04-05T14:50:46","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/aline-desmedt-aline-marighetto-p-v-piazza-in-biol-psy\/"},"modified":"2018-04-05T16:50:46","modified_gmt":"2018-04-05T14:50:46","slug":"aline-desmedt-aline-marighetto-p-v-piazza-in-biol-psy","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/aline-desmedt-aline-marighetto-p-v-piazza-in-biol-psy\/","title":{"rendered":"Aline Desmedt, Aline Marighetto, P-V Piazza in Biol Psy<\/em>"},"content":{"rendered":"

September 1st, 2015<\/p>\n

\"\"Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder<\/strong><\/a>
\nAline Desmedt, Aline Marighetto, and Pier-Vincenzo Piazza<\/em>
\nBiological Psychiatry September 1, 2015; 78:290\u2013297<\/em><\/p>\n

Aline Desmedt is in the team ‘Physiopathology of declarative memory’ of Aline Marighetto at Neurocentre Magendie.<\/p>\n

 <\/p>\n

\n

\"\" <\/strong>Abstract PubMed<\/strong><\/h2>\n

For over a century, clinicians have consistently described the paradoxical co-existence in posttraumatic stress disorder (PTSD) of sensory intrusive hypermnesia and declarative amnesia for the same traumatic event. Although this amnesia is considered as a critical etiological factor of the development and\/or persistence of PTSD, most current animal models in basic neuroscience have focused exclusively on the hypermnesia, i.e., the persistence of a strong fear memory, neglecting the qualitative alteration of fear memory. The latest is characterized by an underrepresentation of the trauma in the context-based declarative memory system in favor of its overrepresentation in a cue-based sensory\/emotional memory system. Combining psychological and neurobiological data as well as theoretical hypotheses, this review supports the idea that contextual amnesia is at the core of PTSD and its persistence and that altered hippocampal-amygdalar interaction may contribute to such pathologic memory. In a first attempt to unveil the neurobiological alterations underlying PTSD-related hypermnesia\/amnesia, we describe a recent animal model mimicking in mice some critical aspects of such abnormal fear memory. Finally, this line of argument emphasizes the pressing need for a systematic comparison between normal\/adaptive versus abnormal\/maladaptive fear memory to identify biomarkers of PTSD while distinguishing them from general stress-related, potentially adaptive, neurobiological alterations.<\/p>\n

More information in french :<\/h3>\n

Aline Desmedt :<\/strong> Alors que la plupart des mod\u00e8les animaux actuels de m\u00e9moire traumatique se focalisent sur l\u2019hypermn\u00e9sie li\u00e9e au trauma, cette revue soutient la th\u00e8se selon laquelle l\u2019amn\u00e9sie vis-\u00e0-vis du contexte environnemental du trauma est au c\u0153ur de l\u2019\u00e9tat de stress post-traumatique (ESPT). Un mod\u00e8le de m\u00e9moire de type ESPT r\u00e9cemment mis au point chez la souris y est d\u00e9crit : il fournit le moyen de distinguer une m\u00e9moire normale et adaptative d\u2019un \u00e9pisode de stress d\u2019une m\u00e9moire traumatique pathologique, incluant, elle, une telle amn\u00e9sie. Cette distinction est mise en exergue dans la mesure o\u00f9 elle s\u2019av\u00e8re cruciale pour l\u2019identification de biomarqueurs de l\u2019ESPT, lesquels diff\u00e8rent n\u00e9cessairement des alt\u00e9rations biologiques adaptatives induites par un stress.”<\/p>\n","protected":false},"excerpt":{"rendered":"

Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-20573","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=20573"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20573\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=20573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=20573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=20573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}