{"id":20562,"date":"2018-04-05T15:59:48","date_gmt":"2018-04-05T13:59:48","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/m-potier-f-georges-et-a-marighetto-inbiol-psy\/"},"modified":"2018-04-05T15:59:48","modified_gmt":"2018-04-05T13:59:48","slug":"m-potier-f-georges-et-a-marighetto-inbiol-psy","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/m-potier-f-georges-et-a-marighetto-inbiol-psy\/","title":{"rendered":"M.Potier, F.Georges et A.Marighetto inBiol Psy<\/em>"},"content":{"rendered":"

Le 22 septembre 2015<\/p>\n

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Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.<\/strong><\/a>\u00a0<\/em>Potier M, Georges F, Brayda-Bruno L, Lad\u00e9p\u00eache L, Lamothe V, Al Abed AS, Groc L, Marighetto A.\u00a0<\/em>Biol Psychiatry. 2015 Jul 31. pii: S0006-3223(15)00611-3. doi: 10.1016\/j.biopsych.2015.07.017.<\/em><\/p>\n

Laboratoire d’Aline Marighetto \/ Team leader – Pathophysiology of declarative memory<\/strong>
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\"\"<\/span> La formation de la m\u00e9moire d\u00e9clarative, c\u2019est-\u00e0-dire la capacit\u00e9 de m\u00e9moriser les \u00e9v\u00e8nements de notre vie associ\u00e9s \u00e0 leur contexte spatio-temporel (quoi-o\u00f9-quand?),<\/em><\/strong> est une capacit\u00e9 cognitive majeure qui d\u00e9cline dans de nombreux syndromes neuropsychiatriques li\u00e9s au vieillissement ou au stress.<\/p>\n

L\u2019estradiol poss\u00e8de un bon potentiel th\u00e9rapeutique vis-\u00e0-vis de ce d\u00e9ficit, car cette hormone sexuelle st\u00e9ro\u00efde est un modulateur puissant de la plasticit\u00e9 synaptique hippocampique d\u00e9pendante des r\u00e9cepteurs NMDA, suppos\u00e9e sous-tendre le stockage des associations complexes qui composent la m\u00e9moire d\u00e9clarative. R\u00e9cemment, l\u2019\u00e9quipe de L. Groc a montr\u00e9 que les r\u00e9cepteurs NMDA sont mobiles \u00e0 la surface de la synapse et que cette mobilit\u00e9 contribue \u00e0 la maturation synaptique des neurones hippocampiques.<\/p>\n

\"\"<\/a><\/span> Toutefois la contribution de la mobilit\u00e9 de surface des r\u00e9cepteurs NMDA<\/strong> \u00e0 la formation de la m\u00e9moire restait \u00e0 d\u00e9montrer. C\u2019est ce que nous avons fait dans ce travail, en combinant des approches d\u2019imagerie cellulaire in vitro,<\/em> d\u2019\u00e9lectrophysiologie in vivo <\/em>et des tests comportementaux \u00e9valuant les diff\u00e9rentes dimensions associatives de la m\u00e9moire d\u00e9clarative. Nous montrons que la mobilit\u00e9 de surface des r\u00e9cepteurs NMDA est n\u00e9cessaire \u00e0 la plasticit\u00e9 des synapses hippocampiques, induite par la stimulation t\u00e9tanique des synapses CA3-CA1 ou par l\u2019infusion intra-hippocampique d\u2019estradiol, qui s\u2019av\u00e8re \u00eatre un puissant modulateur de la distribution de surface des r\u00e9cepteurs NMDA.<\/p>\n

Nous montrons aussi que la mobilit\u00e9 de surface contribue \u00e0 la m\u00e9morisation puisqu\u2019elle est requise, en particulier dans le champ CA1 de l\u2019hippocampe, pour le stockage des associations temporelles et l\u2019am\u00e9lioration de ce stockage par l\u2019estradiol. Cette d\u00e9couverte d\u2019un nouveau m\u00e9canisme dans la formation de la m\u00e9moire d\u00e9clarative et sa modulation par l\u2019estradiol, ouvre de nouvelles pistes pour la recherche th\u00e9rapeutique.”<\/p>\n

\u00a0<\/em>Myl\u00e8ne Potier, Ph.D. \/ mailto:mylene.potier(at)inserm.fr<\/p>\n

Premiers co-auteurs<\/h3>\n
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Myl\u00e8ne Potier Team ‘Pathophysiology of declarative memory ‘, group leader: Aline Marighetto, Ing\u00e9nieur de Recherche, Bordeaux Sciences Agro<\/figcaption><\/figure>\n

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Fran\u00e7ois Georges Researcher PhD CNRS Team: Development and adaptation of neuronal circuits IINS
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\n<\/strong><\/em><\/p>\n

Derni\u00e8re mise \u00e0 jour le 22.09.2015<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors. <\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-20562","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=20562"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/20562\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=20562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=20562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=20562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}