{"id":198093,"date":"2026-05-04T18:17:48","date_gmt":"2026-05-04T16:17:48","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=198093"},"modified":"2026-05-07T08:30:45","modified_gmt":"2026-05-07T06:30:45","slug":"seminar-megan-fox","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/seminar-megan-fox\/","title":{"rendered":"Seminar \u2013 Megan Fox"},"content":{"rendered":"

Monday 11 May \/ 11:30<\/span><\/strong><\/p>\n

Venue: Centre Broca<\/strong><\/p>\n

\n

\"\"<\/a>Megan E Fox, PhD.<\/a><\/strong>
\nAssistant Professor and Garfield B. Russell Career Development Professor in Medical Education
\nDepartment of Anesthesiology,
\nDepartment of Neuroscience and Experimental Therapeutics,
\nPenn State College of Medicine
\nPennsylvania State University<\/a><\/p>\n

Invited by Michel Engeln (INCIA)<\/p>\n

Title<\/h3>\n

Molecular mechanisms underlying risk and resilience to opioid seeking<\/p>\n

Abstract<\/h3>\n

The neurobiological mechanisms that confer vulnerability or resilience to opioid use disorder remain incompletely understood. Our work examines how individual differences in circuit function and stress sensitivity shape opioid seeking and relapse-like behavior, integrating molecular, circuit-based, and behavioral approaches in mice. Recent findings from our lab reveal that alterations in dopamine D1 receptor\u2013expressing medium spiny neurons can profoundly influence fentanyl seeking without broadly disrupting reward learning or drug intake. These differences are accompanied by changes in dopamine receptor signaling, gene expression, dendritic complexity, and circuit function. Ongoing work extends these observations to show that stress exposure and stress susceptibility interact with mesolimbic circuitry to further influence opioid-related behaviors, highlighting stress as a key modulator of individual risk and resilience.<\/p>\n

\n

With the support of Bordeaux Neurocampus<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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