{"id":197612,"date":"2026-04-22T12:11:55","date_gmt":"2026-04-22T10:11:55","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/friday-seminar-sylvie-lorthois\/"},"modified":"2026-04-22T12:11:55","modified_gmt":"2026-04-22T10:11:55","slug":"friday-seminar-sylvie-lorthois","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/friday-seminar-sylvie-lorthois\/","title":{"rendered":"Friday Seminar \u2013 Sylvie Lorthois"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><div class=\"tribe-events-schedule tribe-clearfix\">\n<p><strong><span class=\"tribe-event-date-start\">Friday 24 April \/ 11:30<\/span><\/strong><\/p>\n<\/div>\n<div id=\"post-189006\" class=\"post-189006 tribe_events type-tribe_events status-publish hentry tribe_events_cat-for-scientists tribe_events_cat-home-event tribe_events_cat-incia-en tribe_events_cat-seminars cat_for-scientists cat_home-event cat_incia-en cat_seminars\">\n<div class=\"tribe-events-single-event-description tribe-events-content\">\n<div class=\"wpb-content-wrapper\">\n<div class=\"vc_row wpb_row vc_row-fluid\">\n<div class=\"wpb_column vc_column_container vc_col-sm-8\">\n<div class=\"vc_column-inner\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element\">\n<div class=\"wpb_wrapper\">\n<p><strong>Venue: Centre Broca<\/strong><\/p>\n<hr \/>\n<p><strong><a href=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois.png\" rel=\"lightbox[189006]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-196561\" src=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois.png\" sizes=\"auto, (max-width: 203px) 100vw, 203px\" srcset=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois.png 203w, https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois-80x80.png 80w\" alt=\"\" width=\"203\" height=\"203\" \/><\/a>Sylvie Lorthois<br \/>\n<\/strong>Directrice de Recherche CNRS<br \/>\nPorous and Biological Media Group \u2013 Institut de M\u00e9canique des Fluides de Toulouse<br \/>\n<a href=\"https:\/\/www.imft.fr\/pages-personnelles\/lorthois-sylvie\/\">www.imft.fr\/<\/a><\/p>\n<p>Invited by Jean-Luc Morel (INCIA)<\/p>\n<h3>Title<\/h3>\n<p>In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer\u2019s Disease.<\/p>\n<h3>Abstract<\/h3>\n<p>The cerebral microvascular system is essential to a large variety of physiological processes in the brain, including blood delivery, neurotoxic waste clearance and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It also plays a major role in disease (stroke, neurodegenerative diseases, \u2026). However, the functional consequences of vascular damage (including acute occlusions or long-term remodeling in ageing or disease) are poorly understood.<\/p>\n<p>In this context, in silico modeling approaches are increasingly important, and enable to integrate the specific multi-scale architecture of the brain microvascular network with the physics of blood flow in confined conditions. I will discuss how the resulting scaling-laws for blood flow and molecular transport are mostly driven by the topology of the microvascular network, deterministically leading to the emergence of hypoxic pockets in sub-cortical regions under mild hypoperfusion. I will highlight how these results help understand the overlap between cerebrovascular and Alzheimer\u2019s Disease.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Friday 24 April \/ 11:30 \/\/ In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer\u2019s Disease.<\/p>\n","protected":false},"author":108,"featured_media":197613,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-197612","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evenement-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/197612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=197612"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/197612\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/197613"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=197612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=197612"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=197612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}