{"id":197364,"date":"2026-04-09T11:13:23","date_gmt":"2026-04-09T09:13:23","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=197364"},"modified":"2026-04-09T11:29:33","modified_gmt":"2026-04-09T09:29:33","slug":"marneffe-et-al-in-current-biology","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/marneffe-et-al-in-current-biology\/","title":{"rendered":"Marneffe et al. in Current Biology<\/em>"},"content":{"rendered":"

There is a strong agreement that memories are stored by means of activity-dependent changes in the strength of synapses \u2013 a process called synaptic plasticity<\/strong>. A very large majority of studies linking synaptic plasticity and memory relate to long term changes in post-synaptic parameters<\/strong>.<\/p>\n

In a \u00a0recent article published in Current Biology, Catherine Marneffe – a former PhD student under the supervision of Christophe Mulle at the Interdisciplinary Institute of Neuroscience (IINS) – has explored the circuit and behavioural consequences<\/strong> of removing presynaptic short plasticity<\/strong> at an identified hippocampal synapse.<\/p>\n

Hippocampal mossy fiber synapses, which connect the dentate gyrus to the CA3 region, are dubbed “detonator” synapses due to their remarkable level of presynaptic short-term facilitation. These properties have long been thought to play a role in memory acquisition based on computational analyses, albeit with no experimental demonstration of these hypotheses. Here, Marneffe et al. have selectively suppressed the calcium sensor Synaptotagmin 7 in presynaptic mossy fibers in mice, leading to a precise abrogation of presynaptic short-term plasticity<\/strong>. This impacts the activity of CA3 circuits in vivo<\/em>, by impairing the co-activity of ensembles of CA3 pyramidal cells. In turn, these mice show deficits in spatial memory tasks that rely on the process of pattern completion, but not on pattern separation.<\/p>\n

These results give important insights into how the remarkable detonator properties<\/strong> of DG-CA3 synapses contribute to hippocampal function at the circuit and behavioral levels.<\/p>\n

 <\/p>\n

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Graphical abstract<\/figcaption><\/figure>\n

 <\/p>\n

Reference <\/strong><\/h3>\n

Catherine Marneffe<\/strong>,\u00a0<\/span><\/span> Noelle Grosjean<\/strong>, <\/span><\/span>Kyrian Nicolay-Kritter<\/strong>, <\/span><\/span>C\u00e9cile Chatras<\/strong>, <\/span><\/span><\/span>Evan R. Harrell<\/strong>, <\/span><\/span>Ashley Kees<\/strong>, <\/span><\/span>Christophe Mulle<\/strong>#.<\/span><\/span><\/span><\/span><\/p>\n

Abrogation of presynaptic facilitation at hippocampal mossy fiber synapses disrupts neural ensemble activity and spatial memory.<\/a><\/strong><\/p>\n

# : Corresponding authors<\/p>\n

Contacts: christophe.mulle@u-bordeaux.fr<\/p>\n

DOI: 10.1016\/j.cub.2026.02.027 <\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Abrogation of presynaptic facilitation at hippocampal mossy fiber synapses disrupts neural ensemble activity and spatial memory.<\/p>\n","protected":false},"author":357,"featured_media":197365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-197364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/197364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/357"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=197364"}],"version-history":[{"count":2,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/197364\/revisions"}],"predecessor-version":[{"id":197376,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/197364\/revisions\/197376"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/197365"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=197364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=197364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=197364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}