{"id":196939,"date":"2026-04-02T16:39:02","date_gmt":"2026-04-02T14:39:02","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=196939"},"modified":"2026-04-03T11:23:58","modified_gmt":"2026-04-03T09:23:58","slug":"stress-induced-plasminogen-activator-inhibitor-1-pai-1-as-a-blood-biomarker-and-brain-risk-factor-for-ptsd","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/stress-induced-plasminogen-activator-inhibitor-1-pai-1-as-a-blood-biomarker-and-brain-risk-factor-for-ptsd\/","title":{"rendered":"Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD."},"content":{"rendered":"

Jean-Michel Revest\u2019s team, from Neurocentre Magendie, in collaboration with Aline Desmedt\u2019s teams and clinicians from the French Armed Forces Biomedical Research Institute (IRBA), has published a translational study in *Molecular Psychiatry* identifying the stress-induced type-1 plasminogen activator inhibitor (PAI-1) as a blood biomarker and cerebral risk factor for Post-Traumatic Stress Disorder (PTSD).<\/strong><\/p>\n

\"\"<\/a>Post-traumatic stress disorder (PTSD) is a severe stress-related psychiatric condition triggered by traumatic life-threatening events, characterized notably by an altered memory profile. Although clinically well-documented, no specific biomarker exists. This translational study identifies plasminogen activator inhibitor-1 (PAI-1) as a brain risk factor for PTSD, thereby supporting its potential as a blood-derived biomarker. Mice with genetically ablated PAI-1 were protected from developing a PTSD-like memory profile. Conversely, mice exhibiting PTSD-like cognitive impairment showed increased blood PAI-1 levels, correlating with their profile severity. In the brain, PAI-1 levels were specifically increased in the dorsal hippocampus, a key region for cognitive functions and in the etiology of PTSD. Finally, a longitudinal study of soldiers revealed that those developing PTSD symptoms exhibit rising blood PAI-1 levels over a 12-month period. Its significant association with various indicators of PTSD-related psychological distress attests to PAI-1’s potential as a blood biomarker and brain therapeutic target for PTSD.<\/p>\n

Reference<\/h3>\n

Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD.
\nMol Psychiatry<\/em> (2026).
\nhttps:\/\/doi.org\/10.1038\/s41380-026-03564-w<\/a><\/p>\n

\n
\n
M Mennesson<\/strong>\u00a0<\/span> 1 <\/sup>,\u00a0<\/span><\/span>S Abdelkaoui<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>V Roullot-Lacarri\u00e8re<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>S Tronel<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>A Cathala<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>V Lalanne<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>P L Raux<\/strong>\u00a0<\/span> 2 <\/a><\/sup>,\u00a0<\/span><\/span>L Makrini\u00a0<\/span> 3 <\/sup>,\u00a0<\/span><\/span>E Valjent\u00a0<\/span> 4 <\/sup>,\u00a0<\/span><\/span>A M Duffaud\u00a0<\/span> 5 \u00a0<\/span> 6 <\/sup>,\u00a0<\/span><\/span>D Claverie\u00a0<\/span> 5 \u00a0<\/span> 6 <\/sup>,\u00a0<\/span><\/span>M Vall\u00e9e<\/strong>\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>A Desmed<\/strong>t\u00a0<\/span> 2 <\/sup>,\u00a0<\/span><\/span>M Trousselard\u00a0<\/span> 5 \u00a0<\/span> 6 \u00a0<\/span> 7 \u00a0<\/span> 8 <\/sup>,\u00a0<\/span><\/span>J M Revest<\/strong>\u00a0<\/span> 9 \u00a0<\/span> 10 <\/sup><\/span><\/div>\n<\/div>\n<\/div>\n

1<\/sup> Univ. Bordeaux, Inserm, Neurocentre Magendie, U1215, F-33000, Bordeaux, France. marie.mennesson@gmail.com.
\n2<\/sup> Univ. Bordeaux, Inserm, Neurocentre Magendie, U1215, F-33000, Bordeaux, France.
\n3<\/sup> Institut de G\u00e9nomique Fonctionnelle (IGF), Univ. Montpellier CNRS, Inserm, 34094, Montpellier, France.
\n4<\/sup> Institut for Neurosciences of Montpellier (INM), Univ. Montpellier, CNRS, Inserm, 34000, Montpellier, France.
\n5<\/sup> Unit\u00e9 de Neurophysiologie du Stress, D\u00e9partement Neurosciences & Contraintes Op\u00e9rationnelles, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (IRBA), 91223, Br\u00e9tigny-sur-Orge, France.
\n6<\/sup> French Society for Traumatic Stress Studies (FSTSS), 44600, Saint-Nazaire, France.
\n7<\/sup> \u00c9cole de Psychologues Praticiens (EPP), 23 rue du Montparnasse, 75006, Paris, France.
\n8<\/sup> Univ. Lorraine, Inserm, INSPIIRE, UMR 1319, F-54000, Nancy, France.
\n9<\/sup> Univ. Bordeaux, Inserm, Neurocentre Magendie, U1215, F-33000, Bordeaux, France. jean-michel.revest@inserm.fr.
\n10<\/sup> French Society for Traumatic Stress Studies (FSTSS), 44600, Saint-Nazaire, France. jean-michel.revest@inserm.fr.<\/p>\n","protected":false},"excerpt":{"rendered":"

Travaux de l’\u00e9quipe de JM Revest<\/p>\n","protected":false},"author":108,"featured_media":196945,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-196939","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/196939","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=196939"}],"version-history":[{"count":3,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/196939\/revisions"}],"predecessor-version":[{"id":196950,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/196939\/revisions\/196950"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/196945"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=196939"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=196939"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=196939"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}