{"id":19542,"date":"2016-06-20T15:48:02","date_gmt":"2016-06-20T13:48:02","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/lucile-capuron-julie-lasselin-et-al-in-brain-behav-immun\/"},"modified":"2018-03-22T16:22:14","modified_gmt":"2018-03-22T15:22:14","slug":"lucile-capuron-julie-lasselin-et-al-in-brain-behav-immun","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/lucile-capuron-julie-lasselin-et-al-in-brain-behav-immun\/","title":{"rendered":"Lucile Capuron, Julie Lasselin et al. in Brain Behav Immun.<\/em>"},"content":{"rendered":"

Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects.<\/em><\/strong><\/a>\u00a0Lasselin J, Magne E, Beau C, Aubert A, Dexpert S, Carrez J, Lay\u00e9 S, Forestier D, Ledaguenel P, Capuron L.\u00a0Brain Behav Immun. 2016 May 17. pii: S0889-1591(16)30122-2. doi: 10.1016\/j.bbi.2016.05.013. [Epub ahead of print]\u00a0PMID:27223095<\/em><\/p>\n

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\n<\/span><\/em><\/p>\n

Historique :\u00a0Obesity represents currently a major public health concern.<\/strong>\u00a0Not only related to a greater risk of cancers, metabolic, cardiovascular and musculoskeletal diseases, this disorder is also associated with a higher occurrence of behavioral alterations, including impairment in cognitive functioning. In particular, deficits in cognitive flexibility ( i.e. the ability to shift between one rule to another) have been reported in some obese individuals. Although this alteration is critical, as it can interfere with obesity management and treatment, the underlying mechanisms remain unknown. One potential hypothesized mechanism is inflammation.<\/p>\n

Obesity is indeed characterized by a small but chronic production of inflammatory factors, which may act in the brain and contribute to cognitive alterations. In this study, we sought to assess whether systemic low-grade inflammation (determined by circulating C-reactive [CRP] protein levels) plays a role in altered cognitive flexibility in obese individuals. We showed that obese individuals with higher levels of CRP exhibit reduced cognitive flexibility, while obese individuals with lower levels of this inflammatory marker performed similarly than the normal-weight control group. In addition, our results indicate that combination of obesity and higher level of inflammation predicts significant impairment in cognitive flexibility, while obesity or inflammation alone do not.<\/p>\n

Altogether, these findings support the notion that inflammation represents a major contributor of altered cognitive flexibility in obesity and that a subpopulation of obese subjects (i.e., those with higher level of inflammation) is at higher risk for this impairment.<\/p>\n

R\u00e9sum\u00e9 :\u00a0<\/em>\u00a0Impairment in cognitive flexibility and set shifting abilities has been described in obesity.<\/strong>\u00a0This alteration is critical as it can interfere with obesity management strategies. Recent evidences suggest that chronic low-grade inflammation may be involved in cognitive deficits associated with obesity, but the potential involvement in reduced flexibility remains unknown.<\/p>\n

The objective of this study was to assess the contribution of low-grade inflammation, determined by circulating levels of high-sensitivity C-reactive protein (hsCRP), in reduced cognitive flexibility and shifting abilities of obese subjects relatively to a group of non-obese participants. Performance in the intra\/extra-dimensional set shift (IED) test, extracted from the CANTAB, was assessed in 66 obese subjects and 20 non-obese participants.
\nObese subjects with concentrations of hsCRP above 5mg\/L exhibited reduced performance on the IED test in comparison to obese subjects with lower levels of hsCRP and non-obese participants. This difference was particularly manifest in the number of errors made during the extra-dimensional shift (EDS errors).
\nIn contrast, performance before the extra-dimensional shift was spared. Linear regression analyses revealed that the association between obesity and IED alterations was significant only when the condition hsCRP >5mg\/L was entered in the model.
\nThese findings are important as they indicate that, rather than obesity itself, low-grade inflammation represents a major contributor of IED performance in obese subjects.<\/p>\n

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\n<\/span><\/p>\n

Lucile Capuron, PhD, Research Director, Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro) INRA UMR 1286 – Bordeaux University <\/a>
\nDerni\u00e8re mise \u00e0 jour le 20.06.2016<\/strong><\/p>\n

Auteurs<\/h3>\n\n\n\n
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\n<\/span>Julie Lasselin,<\/em><\/strong> PhD, Post-doc Institute of Medical Psychology and Behavioral Immunobiology, Universit\u00e4tsklinikum Essen, 45 122 Essen, Germany<\/em><\/td>\n		\"\"
\n<\/span>Lucile Capuron,<\/em><\/strong>\u00a0PhD, DR INRA Laboratoire de Nutrition et Neurobiologie Int\u00e9gr\u00e9e (NutriNeuro),<\/a> UMR 1286 INRA-Universit\u00e9 de Bordeaux<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Financement FRM de 250.000 euros \u00a0pour Lucile Capuron le 20 Juin 2016 <\/strong>\u00ab R\u00f4le de l’indol\u00e9amine 2,3-dioxyg\u00e9nase (IDO) dans la physiopathologie et le traitement de la d\u00e9pression majeure \u00bb dans le cadre \u00a0de l\u2019appel \u00e0 projet \u00ab Physiopathologie des maladies psychiatriques \u00bb, visant \u00e0 analyser les m\u00e9canismes physiopathologiques de la d\u00e9pression.<\/p>\n","protected":false},"excerpt":{"rendered":"

Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects.\u00a0Lasselin J, Magne E, Beau C, Aubert A, Dexpert S, Carrez J, Lay\u00e9 S, Forestier D, Ledaguenel P, Capuron L.\u00a0Brain Behav Immun. 2016 May 17. pii: S0889-1591(16)30122-2. doi: 10.1016\/j.bbi.2016.05.013. [Epub ahead of print]\u00a0PMID:27223095 Historique :\u00a0Obesity represents currently a major public health concern.\u00a0Not…<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-19542","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=19542"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19542\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=19542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=19542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=19542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}