{"id":19346,"date":"2018-03-21T15:41:29","date_gmt":"2018-03-21T14:41:29","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/daniela-cota-et-al-in-diabetes\/"},"modified":"2018-03-21T15:41:29","modified_gmt":"2018-03-21T14:41:29","slug":"daniela-cota-et-al-in-diabetes","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/daniela-cota-et-al-in-diabetes\/","title":{"rendered":"Daniela Cota et al. in <em>Diabetes<\/em>"},"content":{"rendered":"<p><a href=\"http:\/\/diabetes.diabetesjournals.org\/content\/early\/2016\/11\/30\/db16-0586\">Inhibiting Microglia Expansion Prevents Diet-induced Hypothalamic and Peripheral Inflammation.\u00a0<\/a>\u00a0Andr\u00e9 C, Guzman-Quevedo O, Rey C, R\u00e9mus-Borel J, Clark S, Castellanos-Jankiewicz A, Ladeveze E, Leste-Lasserre T, Nadjar A, Abrous DN, Laye S, Cota D. \u00a0Diabetes. 2016 Nov 30. pii: db160586. [Epub ahead of print] PMID: 27903745<\/p>\n<hr \/>\n<p>This work was carried out in collaboration with the laboratories of Nora Abrous (INSERM U1215) and Sophie Lay\u00e9 (INRA UMR 1286) and was financially supported by the Labex BRAIN.<\/p>\n<figure id=\"attachment_18369\" aria-describedby=\"caption-attachment-18369\" style=\"width: 150px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-18369\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2018\/03\/daniela-cota.jpg\" alt=\"Daniela cota\" width=\"150\" height=\"203\" \/><figcaption id=\"caption-attachment-18369\" class=\"wp-caption-text\">Daniela cota<\/figcaption><\/figure>\n<p>Daniela Cota:\u00a0&#8220;Cell proliferation, neurogenesis and neuroinflammation within the arcuate nucleus (ARC) of the hypothalamus, are all processes that have been proposed to play a role in the development of diet-induced obesity.\u00a0Whether and how diets with different quantity and quality of macronutrients may affect these cellular responses is poorly understood.<\/p>\n<p>In this study,\u00a0which was just published in\u00a0<em>Diabetes<\/em>, we investigated in mice whether the intertwining between cell proliferation and neuroinflammation may be relevant in determining behavioral and metabolic responses associated with the consumption of a high saturated fat, high carbohydrate diet (HFD), which classically leads to obesity.<\/p>\n<p>Our data demonstrate\u00a0that cell proliferation in the ARC of the hypothalamus depends upon the type of diet consumed and that exposure to a HFD for a short period of time causes an increase in cell proliferation, resulting in microglia expansion.<br \/>\nConversely, pharmacological blockade of cell proliferation prevents both hypothalamic and peripheral inflammation, restores hypothalamic leptin sensitivity and blunts hyperphagia and body weight gain.<br \/>\nBy linking consumption of a HFD\u00a0with hypothalamic pro-inflammatory microglia proliferation and body weight gain, these findings have physiological relevance to humans, many of whom eat food rich in carbohydrates and saturated fats&#8221;<\/p>\n<p><a href=\"mailto:daniela.cota@inserm.fr\">Daniela Cota<\/a>, MD, HDR Group Leader, Group &#8220;Energy Balance and Obesity&#8221; INSERM U1215, Universit\u00e9 de Bordeaux<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibiting Microglia Expansion Prevents Diet-induced Hypothalamic and Peripheral Inflammation.\u00a0\u00a0Andr\u00e9 C, Guzman-Quevedo O, Rey C, R\u00e9mus-Borel J, Clark S, Castellanos-Jankiewicz A, Ladeveze E, Leste-Lasserre T, Nadjar A, Abrous DN, Laye S, Cota D. \u00a0Diabetes. 2016 Nov 30. pii: db160586. [Epub ahead of print] PMID: 27903745 This work was carried out in collaboration with the laboratories of&hellip;<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-19346","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=19346"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19346\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=19346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=19346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=19346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}