{"id":19281,"date":"2018-03-20T17:44:59","date_gmt":"2018-03-20T16:44:59","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/impromptu-seminar-robert-kalb\/"},"modified":"2018-03-20T17:44:59","modified_gmt":"2018-03-20T16:44:59","slug":"impromptu-seminar-robert-kalb","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/impromptu-seminar-robert-kalb\/","title":{"rendered":"Impromptu seminar &#8211; Robert Kalb"},"content":{"rendered":"<p>&#8220;The intricacy of glutamatergic synapses \u2013 some new players in the game&#8221;<\/p>\n<p class=\"content-author\">MD, research scientist at The Children\u2019s Hospital of Philadelphia and a professor of Neurology at the Perelman School of Medicine at the University of Pennsylvania.<\/p>\n<p class=\"content-author\"><strong>Invitant : <\/strong> Olivier Thoumine, PhD, IINS, Team Leader: Cell Adhesion Molecules in Synapse Assembly<\/p>\n<div class=\"clear-B\">\n<hr \/>\n<\/div>\n<div class=\"seminaire-content innertube\">\n<p class=\"label\">Abstract :<\/p>\n<p><strong>During early postnatal life, synaptic activity within circuits sculpt connectivity among neurons. NMDA-R mediated activity-dependent<\/strong> development during a critical period has been well explored and other pathways exist, operate in parallel, that are NMDA-R independent. \u00a0Evidence is provided for a plasticity channel that involves AMPA-R assembled with GluA1, the synaptic scaffolding protein SAP97 and specific SAP97-binding partners including CRIPT.<br \/>\nWhile the cell biological processes governed by GluA1\/SAP97\/CRIPT are just beginning to be explored, they are likely to be critical for normal brain function.<\/p>\n<p>See more..\u00a0<strong><a class=\"simple\" href=\"http:\/\/kalbneuron.com\/\">http:\/\/kalbneuron.com\/<\/a>\u00a0<\/strong> \u00a0Kalb Neuronal Biology Laboratory<\/p>\n<div class=\"publications\">\n<h4>Selected publications<\/h4>\n<p><em>Genetic induction of hypometabolism by ablation of MC4R does not suppress ALS-like phenotypes in the G93A mutant SOD1 mouse model. Doshi S, Gupta P, Kalb RG. Sci Rep. 2017 Oct 13;7(1):13150. doi: 10.1038\/s41598-017-13304-4.<\/em><\/p>\n<p><em>Dopamine induces soluble \u03b1-synuclein oligomers and nigrostriatal degeneration. Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Nat Neurosci. 2017 Nov;20(11):1560-1568. doi: 10.1038\/nn.4641. Epub 2017 Sep 18.<\/em><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;The intricacy of glutamatergic synapses \u2013 some new players in the game&#8221; MD, research scientist at The Children\u2019s Hospital of Philadelphia and a professor of Neurology at the Perelman School of Medicine at the University of Pennsylvania. Invitant : Olivier Thoumine, PhD, IINS, Team Leader: Cell Adhesion Molecules in Synapse Assembly Abstract : During early&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[],"class_list":["post-19281","post","type-post","status-publish","format-standard","hentry","category-seminaire"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=19281"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/19281\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=19281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=19281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=19281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}