{"id":18956,"date":"2018-03-12T15:56:59","date_gmt":"2018-03-12T14:56:59","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/nora-abrous-et-al-inmolecular-psychiatry\/"},"modified":"2018-06-19T09:54:43","modified_gmt":"2018-06-19T07:54:43","slug":"nora-abrous-et-al-inmolecular-psychiatry","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/nora-abrous-et-al-inmolecular-psychiatry\/","title":{"rendered":"Nora Abrous et al. inMolecular Psychiatry<\/em>"},"content":{"rendered":"
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Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior.<\/strong> <\/a>V\u00e9ronique Deroche-Gamonet, Jean-Michel Revest, Jean-Fran\u00e7ois Fiancette, Eric Balado, Muriel Koehl, No\u00eblle Grosjean, Djoher Nora Abrous & Pier-Vincenzo Piazza.
\nMolecular Psychiatry (2018) doi:10.1038\/s41380-018-0038-0. Published online: 05 March 2018<\/p>\n

Neurocentre Magendie \/\u00a0 Team:\u00a0Neurogenesis and physiopathology
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Abstract<\/strong>
\nThe hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.<\/p>\n<\/div>\n

Djoher Nora Abrous \/ Neurogenesis and physiopathology group \/ Neurocentre Magendie \/<\/a><\/p>\n

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More information in french<\/h2>\n

Source Inserm <\/a>, communiqu\u00e9 du 7 mars 2018\u00a0<\/strong><\/p>\n

Les comportements d\u2019addiction aux drogues et la vuln\u00e9rabilit\u00e9 aux rechutes seraient li\u00e9s \u00e0 l\u2019aptitude de notre cerveau \u00e0 produire de nouveaux neurones. C\u2019est la conclusion de chercheurs de l\u2019Inserm du Neurocentre Magendie de l\u2019Universit\u00e9 Bordeaux, obtenue apr\u00e8s avoir observ\u00e9 le comportement de souris ayant appris \u00e0 s\u2019auto-administrer de la coca\u00efne. <\/strong><\/p>\n

Nora Abrous :<\/strong> Dans le cerveau, l\u2019hippocampe est l\u2019un des centres de la m\u00e9moire. Il comprend le gyrus dentel\u00e9, qui pr\u00e9sente la particularit\u00e9 de produire de nouveaux neurones (neurogen\u00e8se) chez l\u2019adulte. Une neurogen\u00e8se anormale est corr\u00e9l\u00e9e \u00e0 de nombreux d\u00e9sordres neuropsychiatriques comme des troubles de la m\u00e9moire ou de l\u2019humeur.<\/p>\n

Bien qu\u2019une relation entre neurogen\u00e8se erratique et addiction \u00e0 la drogue ait d\u00e9j\u00e0 \u00e9t\u00e9 soup\u00e7onn\u00e9e, jusqu\u2019\u00e0 aujourd\u2019hui aucune preuve scientifique concr\u00e8te ne venait \u00e9tayer cette hypoth\u00e8se. Les \u00e9quipes de recherche Inserm de Nora Abrous et de Pier-Vicenzo Piazza, du Neurocentre Magendie (Unit\u00e9 1215) de l\u2019Universit\u00e9 de Bordeaux, se sont pench\u00e9es sur le r\u00f4le de la neurogen\u00e8se dans la d\u00e9pendance \u00e0 la coca\u00efne.<\/p>\n

Deux groupes de souris ont \u00e9t\u00e9 compar\u00e9s : un groupe sain et un groupe g\u00e9n\u00e9tiquement modifi\u00e9 pour que la neurogen\u00e8se au niveau de l\u2019hippocampe soit moindre. Les souris ont \u00e9t\u00e9 entra\u00een\u00e9es \u00e0 s\u2019auto-administrer de la coca\u00efne en introduisant leur nez dans un trou, d\u00e9clenchant ainsi la diffusion par voie intraveineuse de coca\u00efne dans leur sang. Le nombre d\u2019actions \u00e0 fournir pour obtenir une quantit\u00e9 similaire de drogue a ensuite \u00e9t\u00e9 progressivement augment\u00e9. Les chercheurs ont constat\u00e9 que les souris transg\u00e9niques montraient une plus grande motivation (mesur\u00e9e en nombre d\u2019actions dans les trous) \u00e0 \u00ab travailler \u00bb pour obtenir de la coca\u00efne.<\/p>\n

Apr\u00e8s plusieurs semaines de sevrage, les souris ont \u00e9t\u00e9 de nouveau expos\u00e9es \u00e0 l\u2019environnement dans lequel elles avaient appris \u00e0 s\u2019auto-administrer de la coca\u00efne. Les souris transg\u00e9niques ont alors montr\u00e9 une plus grande susceptibilit\u00e9 \u00e0 la rechute en cherchant \u00e0 nouveau \u00e0 d\u00e9clencher l\u2019administration de la drogue.
\nLa transition vers l\u2019addiction est un processus associant l\u2019exposition r\u00e9p\u00e9t\u00e9e \u00e0 des stup\u00e9fiants et une vuln\u00e9rabilit\u00e9 propre \u00e0 chaque individu : en d\u00e9montrant que la neurogen\u00e8se est un facteur cl\u00e9 dans la vuln\u00e9rabilit\u00e9 \u00e0 l\u2019addiction, ces travaux offrent de nouvelles perspectives dans la compr\u00e9hension de la fragilit\u00e9 individuelle face \u00e0 la pharmacod\u00e9pendance.<\/p>\n<\/div>\n<\/div>\n

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Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. <\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-18956","post","type-post","status-publish","format-standard","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/18956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=18956"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/18956\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=18956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=18956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=18956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}