{"id":188169,"date":"2025-09-22T21:11:20","date_gmt":"2025-09-22T19:11:20","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=188169"},"modified":"2025-09-25T11:53:20","modified_gmt":"2025-09-25T09:53:20","slug":"tuberculosis-vulnerability-of-people-with-hiv-a-viral-protein-implicated","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/tuberculosis-vulnerability-of-people-with-hiv-a-viral-protein-implicated\/","title":{"rendered":"Tuberculosis vulnerability of people with HIV: a viral protein implicated"},"content":{"rendered":"

Source : CNRS – Press release<\/strong><\/a><\/p>\n

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According to the World Health Organisation, tuberculosis accounts for one in three deaths among people living with HIV. In fact, even when receiving effective antiretroviral treatment, HIV-positive individuals are 15 to 30 times more likely to contract tuberculosis than HIV-uninfected people.<\/span><\/p>\n

In a study published in <\/span>PLOS Pathogens<\/span><\/em>, the CNRS-led research team (<\/span>1) \u00a0highlights the key role played by Tat (<\/span>2) \u00a0<\/sup>\u2013 a viral protein secreted by HIV-infected cells \u2013 in this hyper-vulnerability\u00a0phenomenon. Studies conducted on human cells and zebrafish larvae revealed that this protein blocks the cell defence mechanism known as autophagy, thereby promoting the survival and multiplication of the bacterium responsible for tuberculosis \u2013 <\/span>Mycobacterium tuberculosis<\/span><\/em> \u2013 in target cells (<\/span>3).<\/span><\/p>\n

These findings shed new light on the synergy between HIV and tuberculosis and pave the way for the development of innovative therapeutic strategies. Although the Tat protein remains difficult to target at present, treatments aimed at restoring the autophagy mechanism could be developed to better protect patients.<\/span><\/p>\n

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Notes<\/h2>\n
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  1. From l\u2019Institut de recherche en infectiologie de Montpellier (CNRS\/Universit\u00e9 de Montpellier), Laboratory of Pathogens and Host Immunity (CNRS\/Inserm\/Universit\u00e9 de Montpellier), l\u2019Institut de pharmacologie et biologie structurale (CNRS\/Universit\u00e9 de Toulouse) and l\u2019Institut interdisciplinaire de neurosciences (CNRS\/Universit\u00e9 de Bordeaux).<\/li>\n
  2. Transactivator of transcription.<\/li>\n
  3. Known as macrophages, these cells belong to the white blood cell group. Their main role is to destroy cellular debris and pathogens throughout the body.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n

    R\u00e9f\u00e9rence<\/h3>\n

    HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy.
    \n<\/strong><\/span>A. Rivault, A. Bernut, M. Ben-Neji,\u00a0M. Abrantes,\u00a0M. Jansen, S. Huc-Brandt, S. Besteiro, Y. Bordat, N. Audemard, M. Mesleard-Roux, D. Perrais<\/strong>, O. Neyrolles, G. Lugo-Villarino, C. V\u00e9rollet, L. Espert et B. Beaumelle. PLOS Pathogens<\/em>, 18 septembre 2025.
    \nhttps:\/\/doi.org\/10.1371\/journal.ppat.1013183<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

    David Perrais (IINS) is on of the authors<\/p>\n","protected":false},"author":108,"featured_media":188171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"class_list":["post-188169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications-commentees"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/188169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=188169"}],"version-history":[{"count":3,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/188169\/revisions"}],"predecessor-version":[{"id":188252,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/188169\/revisions\/188252"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/188171"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=188169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=188169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=188169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}