{"id":18314,"date":"2018-03-05T15:07:35","date_gmt":"2018-03-05T14:07:35","guid":{"rendered":"https:\/\/neurodev-ng.u-bordeaux.fr\/?p=18314"},"modified":"2018-03-05T15:08:54","modified_gmt":"2018-03-05T14:08:54","slug":"julie-jezequel-laurent-groc-et-al-in-nature-commun","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/julie-jezequel-laurent-groc-et-al-in-nature-commun\/","title":{"rendered":"Julie J\u00e9z\u00e9quel, Laurent Groc et al. in Nature commun."},"content":{"rendered":"<p>Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients. Julie J\u00e9z\u00e9quel, Emily M. Johansson, Julien P. Dupuis, V\u00e9ronique Rogemond, H\u00e9l\u00e8ne Gr\u00e9a, Blanka Kellermayer, Nora Hamdani, Emmanuel Le Guen, Corentin Rabu, Marilyn Lepleux, Marianna Spatola, Elodie Mathias, Delphine Bouchet, Amy J. Ramsey, Robert H. Yolken, Ryad Tamouza, Josep Dalmau, J\u00e9r\u00f4me Honnorat, Marion Leboyer &amp; Laurent Groc. Nature Communications 8, Article number: 1791 (2017) doi:10.1038\/s41467-017-01700-3 Published online: 27 November 2017<\/p>\n<p>Laurent GROC, Directeur Recherche CNRS, Group Leader IINS,<br \/>\nJulie JEZEQUEL, Postdoctoral Research Assistant, King&#8217;s College London, Department of Developmental Neurobiology &amp; Universit\u00e9 de Bordeaux , Bordeaux Neurocampus<\/p>\n<hr \/>\n<p>The flourishing identification of circulating autoantibodies against neuronal receptors in neuropsychiatric disorders has fostered new conceptual and clinical frameworks. However, their putative presence in different diseases, as well as in healthy subjects, has raised questions about detection reliability and pathogenic role.<\/p>\n<p>Laurent Groc, Julie J\u00e9z\u00e9quel: In a translational study with clinical experts from Europe and US, Julie Jezequel and collaborators have use single molecule-based imaging approaches to ascertain the presence of circulating autoantibodies against glutamate NMDA receptor (NMDAR-Ab) in about 20% of psychotic patients diagnosed with schizophrenia and very few healthy subjects. Strikingly, NMDAR-Ab from patients, but not from healthy subjects, specifically alter the surface dynamics and nanoscale organization of synaptic NMDAR and its anchoring partner the EphrinB2 receptor. Functionally, only patients\u2019 NMDAR-Ab prevent long-term potentiation at glutamatergic synapses while leaving NMDAR-mediated calcium influx intact.<\/p>\n<p>Thus, by taking advantage of the single molecule imaging, we unveil that NMDAR-Ab from psychotic patients profoundly alter NMDAR synaptic transmission, supporting a pathogenically relevant role. This work sheds thus new and unsuspected ligth on the dysfunction of NMDAR signaling in psychotic disorders.<\/p>\n<p>Laurent GROC Directeur Recherche CNRS, Group Leader IINS, CNRS UMR 5297 Centre Broca Nouvelle-Aquitaine Universit\u00e9 de Bordeaux<br \/>\nDerni\u00e8re mise \u00e0 jour le 04.12.2017<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients. Julie J\u00e9z\u00e9quel, Emily M. Johansson, Julien P. Dupuis, V\u00e9ronique Rogemond, H\u00e9l\u00e8ne Gr\u00e9a, Blanka Kellermayer, Nora Hamdani, Emmanuel Le Guen, Corentin Rabu, Marilyn Lepleux, Marianna Spatola, Elodie Mathias, Delphine Bouchet, Amy J. Ramsey, Robert H. Yolken, Ryad Tamouza, Josep Dalmau, J\u00e9r\u00f4me Honnorat, Marion Leboyer&hellip;<\/p>\n","protected":false},"author":108,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-18314","post","type-post","status-publish","format-standard","hentry","category-news-neurocampus"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/18314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=18314"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/18314\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=18314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=18314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=18314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}