{"id":148532,"date":"2022-05-30T16:31:03","date_gmt":"2022-05-30T14:31:03","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/phd-seminar-ana-domingos\/"},"modified":"2022-05-31T14:51:57","modified_gmt":"2022-05-31T12:51:57","slug":"phd-seminar-ana-domingos","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/phd-seminar-ana-domingos\/","title":{"rendered":"PhD seminar – Ana Domingos"},"content":{"rendered":"
\"\"<\/strong>
\nAna Domingos
\n<\/strong>Associate Professor of Neuroscience
\nDept. Physiology, Anatomy, Genetics
\nUniversity of Oxford
\nHHMI \/ Wellcome IRScholar<\/div>\n

Friday 3 June \/ 13:30 (Mind the time!)<\/strong><\/p>\n

Centre Broca.<\/strong><\/p>\n

The seminar will be a recording, broadcast<\/span><\/span> in the auditorium, and followed by Q&A at 2:15pm with the speaker on Zoom (still in the audiorium).<\/p>\n

\n

Title<\/h3>\n

Neuroimmunometabolism<\/p>\n

Abstract<\/h3>\n

My laboratory researches neurobiological mechanisms underlying obesity. First, we discovered neuro-adipose junctions between white adipocytes and sympathetic neurons that constitute a peripheral effector arm of leptin action in the brain (1). Moreover, we discovered\u00a0that this efferent arm is negatively regulated by Sympathetic neuron-Associated\u00a0Macrophages (SAMs) that import NE via the Slc6a2 transporter resulting in its clearance. Abrogation of SAM function promotes long-term mitigation of obesity independently of food intake (2). These findings inspired the development of a new class of anti-obesity compounds named\u00a0sympathofacilitators,\u00a0designed not to enter the brain. Consequently, they do not have the typical cardiovascular side effects of centrally acting sympathomimetic drugs (3).\u00a0\u00a0Sympathofacilitator drugs\u00a0act as an energy sink by coupling thermogenesis to active heat dissipation via the beta2 adrenergic receptor, independently of food intake. Whereas\u00a0druggability<\/em>\u00a0intersects our discovery path, the overall focus of this talk are the fundamental aspects of sympathetic-nerve biology in the context of obesity and metabolic dysfunction. We have coined the term\u00a0Neuroimmunometabolism<\/em>\u00a0to designate the study of the crosstalk between immune cells and neurons controlling whole-body metabolism. Neuroimmunometabolic mechanisms linking inflammation to SNS neuronal function, and leptin resistance will be discussed (4).<\/p>\n

References:<\/em><\/strong><\/p>\n

1) Zeng W*, Pirzgalska RM*; Pereira MMA; Kubasova N; Barateiro A; Seixas E; Lu YH; Kozlova A; Voss H; Martins GG;\u00a0 Friedman JM,\u00a0\u00a0Domingos AI<\/strong>\u03c8<\/sup><\/strong>\u00a0(2015). Sympathetic Neuro-Adipose Connections Mediate Leptin-Driven Lipolysis.\u00a0Cell.<\/u>\u00a0<\/em>163(1):84\u201394,<\/p>\n

2)Roksana M Pirzgalska*,Elsa Seixas*,Jason S Seidman, Verena M Link, Noelia Mart\u00ednez S\u00e1nchez, In\u00eas Mah\u00fa, Raquel Mendes, Vitka Gres, Nadiya Kubasova, Imogen Morris, Bernardo A Ar\u00fas, Chelsea M Larabee, Miguel Vasques, Francisco Tortosa, Ana L Sousa, Sathyavathy Anandan, Erin Tranfield, Maureen K Hahn, Matteo Iannacone, Nathanael J Spann, Christopher K Glass &\u00a0Ana I Domingos<\/strong>\u00a0<\/strong>\u03c8<\/strong>\u00a0(2017).\u00a0Sympathetic neuron\u2013associated macrophages contribute to obesity by importing and metabolizing norepinephrine.\u00a0Nature Medicine.<\/u><\/em><\/p>\n

3) Brain-sparing\u00a0sympathofacilitators<\/em>\u00a0mitigate obesity without adverse cardiovascular effects.
\nMah\u00fa I, Barateiro A, Rial-Pensado E, Martin\u00e9z-S\u00e1nchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Tempor\u00e3o C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebasti\u00e3o AM, L\u00f3pez M, Bernardes GJL,\u00a0Domingos AI,\u00a0<\/strong>Cell Metabolism<\/u><\/em>\u00a0June 2nd;31(6):1120-1135 (2020)<\/p>\n

4) Domingos, A.I. Leptin: a missing piece in the immunometabolism puzzle.\u00a0Nature Rev Immunol\u00a0<\/u><\/em>20,\u00a0<\/strong>3 (2020).<\/p>\n

\n

Organized by Bordeaux Neurocampus, NBA and Bordeaux Neurocampus Graduate Program<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

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