![\"D\u00e9tection](\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/10\/vanhoutte-october21-Image_5.jpg\")
<\/a>\u00a9 Andry Andrianarivelo and Peter Vanhoutte\u2014Neuroscience Paris Seine laboratory (CNRS\u00a0\/\u00a0Sorbonne University\u00a0\/\u00a0INSERM)<\/figcaption><\/figure>\n
Drug addiction is a psychiatric disorder for which no pharmacological treatment with long-term efficacy currently exists. All addictive substances share the property of raising concentrations of the neurotransmitter dopamine within brain regions forming the neural reward circuit. This increase in dopamine levels results in long-lasting alteration of signal transmission that is dependent on another neurotransmitter, glutamate, which causes addictive behaviours.<\/p>\n
Through a new study, an international team including scientists from the CNRS, INRAE, the CEA, Sorbonne University, Paris-Saclay University, the University of Bordeaux, and Universit\u00e9 C\u00f4te d\u2019Azur* has uncovered, in mice and humans, the molecular bases of this deleterious interplay between dopamine and glutamate. The researchers\u2019 work shows that the inhibition of interactions between dopamine and glutamate receptors prevents pathological behaviours provoked by cocaine in mice, without altering natural reward processing. Their findings, published in Science Advances<\/em> (20 October 2021), pave the way for the development of new therapeutic strategies to treat addiction, and a wider spectrum of psychiatric disorders.<\/p>\n Note<\/strong><\/p>\n *These scientists are affiliated with the Neuroscience Paris Seine laboratory (CNRS \/ Sorbonne University \/ INSERM), the Institute of Molecular and Cellular Pharmacology (CNRS \/ Universit\u00e9 C\u00f4te d\u2019Azur), the Neurogenerative Disease Laboratory (CNRS \/ CEA \/ Paris-Saclay University), and the NutriNeuro research unit (INRAE \/ Bordeaux INP \/ University of Bordeaux).<\/p>\n