{"id":133783,"date":"2021-04-12T20:47:09","date_gmt":"2021-04-12T18:47:09","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=133783"},"modified":"2021-04-22T16:24:39","modified_gmt":"2021-04-22T14:24:39","slug":"c-bouarab-v-roullot-lacarriere-a-desmedt-p-v-piazza-j-m-revest-in-mol-psy","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/c-bouarab-v-roullot-lacarriere-a-desmedt-p-v-piazza-j-m-revest-in-mol-psy\/","title":{"rendered":"C. Bouarab, V. Roullot-Lacarri\u00e8re,  A. Desmedt, P. V. Piazza, J. M. Revest in <em>Mol Psy<\/em>"},"content":{"rendered":"<h3>Comment<\/h3>\n<p>Glucocorticoid hormones (GC) have been proposed as one of the biological systems involved in the transition from adaptive to pathological PTSD-like fear memory. In this collaborative paper with Aline Desmedt\u2019s team, we have shown that the deregulation in the hippocampus of the <strong>G<\/strong>R-tPA-BDNF-TrkB-Erk1\/2<strong>M<\/strong>APK-<strong>E<\/strong>gr-1-<strong>S<\/strong>ynapsin-I (<strong>GMES<\/strong>) signaling cascade via the increase of type-1 Plasminogen Activator Inhibitor (PAI-1), induced by intense or traumatic stress and GC, is responsible for the formation of a pathological memory modeling important aspects of PTSD. We have shown that pharmacological inhibition of PAI-1 activity prevented PTSD-like memory formation.<\/p>\n<h3>Abstract<\/h3>\n<p><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/04\/Figure-revest.jpg\" rel=\"lightbox[133783]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-133778\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/04\/Figure-revest-296x360.jpg\" alt=\"\" width=\"296\" height=\"360\" srcset=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/04\/Figure-revest-296x360.jpg 296w, https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/04\/Figure-revest-633x770.jpg 633w, https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2021\/04\/Figure-revest.jpg 1344w\" sizes=\"auto, (max-width: 296px) 100vw, 296px\" \/><\/a>Moderate stress increases memory and facilitates adaptation. In contrast, intense stress can induce pathological memories as observed in post-traumatic stress disorders (PTSD). A shift in the balance between the expression of tPA and PAI-1 proteins is responsible for this transition. In conditions of moderate stress, glucocorticoid hormones increase the expression of the tPA protein in the hippocampal brain region which by triggering the Erk1\/2MAPK signaling cascade strengthens memory. When stress is particularly intense, very high levels of glucocorticoid hormones then increase the production of PAI-1 protein, which by blocking the activity of tPA induces PTSD-like memories. PAI-1 levels after trauma could be a predictive biomarker of the subsequent appearance of PTSD and pharmacological inhibition of PAI-1 activity a new therapeutic approach to this debilitating condition.<\/p>\n<h2>Reference<\/h2>\n<p><strong>PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory. <\/strong>*Bouarab C, *Roullot-Lacarri\u00e8re V, Vall\u00e9e M, Le Roux A, Guette C, Mennesson M, Marighetto A, *Desmedt A, *Piazza PV, *Revest JM. Mol Psychiatry. 2021 Jan 28.<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/s41380-021-01024-1\">DOI: 10.1038\/s41380-021-01024-1<\/a> Online ahead of print. PMID: 33510345.<\/p>\n<p>*co-authorship<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PAI-1 protein is a key molecular effector in the transition from normal to PTSD-like fear memory<\/p>\n","protected":false},"author":108,"featured_media":133782,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-133783","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/133783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=133783"}],"version-history":[{"count":2,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/133783\/revisions"}],"predecessor-version":[{"id":133785,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/133783\/revisions\/133785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/133782"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=133783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=133783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=133783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}