{"id":129414,"date":"2020-12-17T10:52:53","date_gmt":"2020-12-17T09:52:53","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=129414"},"modified":"2026-02-10T17:46:54","modified_gmt":"2026-02-10T16:46:54","slug":"jerome-baufreton-and-nicolas-mallet-in-current-biology","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/jerome-baufreton-and-nicolas-mallet-in-current-biology\/","title":{"rendered":"J\u00e9r\u00f4me Baufreton and Nicolas Mallet in Current Biology<\/em>"},"content":{"rendered":"

The basal ganglia play a crucial role in controlling\u00a0locomotion as best evinced by the motor symptoms present in Parkinson\u2019s disease\u00a0following their dysfunctions. However, the neuronal mechanisms involved in such\u00a0locomotor\u00a0control are not precisely known. In this paper authored by Asier\u00a0Aristieta et al., we discovered a novel\u00a0basal ganglia circuit mechanism that, when recruited, causes a powerful\u00a0and global state of motor suppression. Our work calls for a re-evaluation of\u00a0basal ganglia functional organization that\u00a0should account for the critical role\u00a0played by globus pallidus arkypallidal neurons in action selection\/cancellation.\u00a0This publication results from co-investigations\u00a0within two teams of the IMN (J. Baufreton and N. Mallet) and a collaboration with\u00a0the AniMotion\u00a0collaborative platform from\u00a0INCIA (G. Barri\u00e8re\/G. Courtand).<\/p>\n

Abstract<\/h3>\n

\"\"<\/a>Basal ganglia (BG) inhibit movements through two independent circuits: the striatal-indirect and the subthalamic nucleus-hyperdirect pathways. Both pathways exert opposite effects onto external globus pallidus (GP) neurons which functional importance as a relay has changed drastically with the discovery of two distinct cell types, namely the prototypic and the arkypallidal neurons. However, little is known about the synaptic connectivity scheme of different GP neurons towards both motor-suppressing pathways, as well as how opposite changes in GP neuronal activity relate to locomotion inhibition. Here, we optogenetically dissect the inputs organizations of prototypic and arkypallidal neurons, and further define the circuit mechanism and behavioural outcome associated with activation of the indirect or the hyperdirect pathways. This work reveals that arkypallidal neurons are part of a novel disynaptic feedback loop differentially recruited by the indirect or the hyperdirect pathways and that broadcast inhibitory control onto locomotion only when arkypallidal neurons increased their activity.<\/p>\n

In this article, the authors show a cell-type specific connectivity within the external globus pallidus which lead to opposite activity pattern between prototypic and arkypallidal neurons and opposite outcome on movement inhibition. Selective optogenetic activation of arkypallidal neurons is sufficient to stop locomotion on a treadmill and uncover the key function of these neurons is suppressing ongoing locomotion.<\/p>\n

This video<\/strong> illustrates the powerful inhibitory effect that Arkypallidal neurons optogenetic activation has on the locomotor activity of a mice walking on a motorized treadmill. The locomotor video sequence was captured bilaterally (i.e. left and right view) at 250 frames\/seconde.<\/p>\n

 <\/p>\n

Reference<\/h3>\n

Aristieta A, Barresi M, Azizpour Lindi S, Barri\u00e8re G, Courtand G, de la Crompe B, Guilhemsang L, Gauthier S, Fioramonti S, Baufreton J, Mallet NP.
\nA Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition. <\/a>
\nCurr Biol<\/em>. 2020 Dec 3:S0960-9822(20)31694-8.<\/p>\n

doi: 10.1016\/j.cub.2020.11.019<\/p>\n

Contact<\/h3>\n

J\u00e9r\u00f4me Baufreton<\/strong>, jerome.baufreton@u-bordeaux.fr<\/a>
\nTeam “Dopamine et Assembl\u00e9es Neuronales”
\nInstitut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR5293, CNRS, Universit\u00e9 de Bordeaux<\/p>\n

Nicolas Mallet<\/strong>, nicolas.mallet@u-bordeaux.fr<\/a>
\nTeam “Physiologie et physiopathologie des fonctions ex\u00e9cutives”
\nInstitut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives, UMR5293, CNRS, Universit\u00e9 de Bordeaux<\/p>\n","protected":false},"excerpt":{"rendered":"

A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition.<\/p>\n","protected":false},"author":108,"featured_media":129416,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-129414","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/129414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=129414"}],"version-history":[{"count":1,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/129414\/revisions"}],"predecessor-version":[{"id":194209,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/129414\/revisions\/194209"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/129416"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=129414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=129414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=129414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}