{"id":126698,"date":"2020-10-27T14:23:30","date_gmt":"2020-10-27T13:23:30","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/monthly-conference-phd-webinar-aline-desmedt\/"},"modified":"2020-10-27T14:23:30","modified_gmt":"2020-10-27T13:23:30","slug":"monthly-conference-phd-webinar-aline-desmedt","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/monthly-conference-phd-webinar-aline-desmedt\/","title":{"rendered":"Monthly conference (PhD webinar) &#8211; Aline Desmedt"},"content":{"rendered":"<p><strong>Aline Desmedt<\/strong><br \/>\nTeam \u00ab\u00a0Pathophysiology of declarative memory\u00a0\u00bb<br \/>\nNeurocentre Magendie<\/p>\n<h4>The hippocampus at the core of PTSD-like memory<\/h4>\n<p>Post-traumatic stress disorder (PTSD) is characterized by a paradoxical memory alteration with hypermnesia for salient traumatic cues and amnesia for the traumatic context. Clinical studies strongly suggest that a deficit in trauma contextualization would leave traumatic memory out of control and thus prone to be automatically reactivated upon trauma-related cues in any context through flashbacks. In this view, recovery from PTSD-related hypermnesia would thus depend on recovery from contextual amnesia. Yet, preclinical research focuses exclusively on the emotional hypermnesia, leaving unexplored the putative causal role of a deficit in the hippocampus-dependent trauma contextualization in PTSD.<\/p>\n<p>Using the first animal model that precisely recapitulates PTSD-related hypermnesia and amnesia, we first show that compared to normal fear memory, PTSD-like fear memory is specifically associated with hippocampal hypoactivation and neuronal alterations. Second, we show that optogenetic inhibition of the hippocampus (dCA1) during stress can produce PTSD-like memory in mice, whereas activating the dCA1 prevents its formation and promotes normal contextual fear memory. Finally, trauma re-contextualization normalizes PTSD-like memory, promoting the expression of a long-lasting normal fear memory.<\/p>\n<p>These findings indicate that PTSD-like memory depends on contextual amnesia and that promoting the hippocampal function promotes a switch from PTSD-like to normal fear memory <em>via<\/em> trauma contextualization. Therefore, these data call for promoting therapeutic approaches of PTSD centered on trauma contextualization and its underlying hippocampal mechanisms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The hippocampus at the core of PTSD-like memory. Friday 6 November<\/p>\n","protected":false},"author":108,"featured_media":126694,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-126698","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evenement-en"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=126698"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126698\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/126694"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=126698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=126698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=126698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}