{"id":126434,"date":"2020-10-14T10:28:54","date_gmt":"2020-10-14T08:28:54","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/muriel-koehl-et-lucile-capuron-laureates-de-la-frm\/"},"modified":"2020-10-15T18:53:20","modified_gmt":"2020-10-15T16:53:20","slug":"muriel-koehl-et-lucile-capuron-laureates-de-la-frm","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/muriel-koehl-et-lucile-capuron-laureates-de-la-frm\/","title":{"rendered":"Appel \u00e0 projets 2020 FRM"},"content":{"rendered":"

F\u00e9licitations aux laur\u00e9at(s)s de l’appel \u00e0 projets 2020 de la FRM “Environnement et Sant\u00e9”.<\/p>\n

Muriel Koehl (Neurocentre Magendie)<\/h3>\n

Projet :<\/strong> Stress d\u00e9veloppemental et troubles de la sant\u00e9 mentale : \u00e0 la recherche de m\u00e9canismes neurobiologiques (Devstress)<\/p>\n

Il est dor\u00e9navant admis que les phases pr\u00e9coces du d\u00e9veloppement sont tr\u00e8s sensibles \u00e0 des influences environnementales d\u00e9l\u00e9t\u00e8res telles que le stress pr\u00e9natal, qui constitue un facteur de risque au d\u00e9veloppement de troubles psychiatriques comme d\u00e9pression, trouble de stress post-traumatique, ou encore troubles anxieux. La p\u00e9riode pr\u00e9natale est donc de plus en plus consid\u00e9r\u00e9e comme une cible cruciale pour la pr\u00e9vention primaire des troubles neurod\u00e9veloppementaux et psychiatriques, mais la compr\u00e9hension de leurs m\u00e9canismes physiopathologiques demeure un d\u00e9fi.<\/p>\n

L\u2019objectif de notre projet est d\u2019analyser les m\u00e9canismes par lesquels le stress pr\u00e9natal peut conduire \u00e0 l\u2019\u00e9mergence de ces pathologies. Pour cela nous couplerons une approche clinique \u00e9pid\u00e9miologique ayant pour but de relier l\u2019activit\u00e9 de l\u2019axe du stress maternel \u00e0 la trajectoire d\u00e9veloppementale des enfants. L\u2019hypoth\u00e8se retenue est que l\u2019exc\u00e8s de cortisol maternel cons\u00e9cutif \u00e0 un stress gestationnel pourrait entrainer un dysfonctionnement de l\u2019axe corticotrope de l\u2019enfant qui serait \u00e0 l\u2019origine d\u2019une plus grande vuln\u00e9rabilit\u00e9 au d\u00e9veloppement de pathologies. Ce volet \u00e9pid\u00e9miologique d\u00e9velopp\u00e9 par l\u2019\u00e9quipe du Dr. Judith van der Waerden (Institut Pierre Louis d’Epid\u00e9miologie et de Sant\u00e9 Publique)<\/em> <\/strong>sera compl\u00e9t\u00e9 par un volet fondamental reposant sur un mod\u00e8le murin de stress pr\u00e9natal qui nous permettra d\u2019une part de valider l\u2019hypoth\u00e8se clinique et d\u2019autre part d\u2019en \u00e9tudier les m\u00e9canismes. En collaboration avec les \u00e9quipes des Drs. Aline Desmedt (Neurocentre magendie) et Fran\u00e7ois Georges (Institut des maladies neurod\u00e9g\u00e9n\u00e9ratives)<\/strong>, nous analyserons et manipulerons l\u2019activit\u00e9 du r\u00e9seau cortico-hippocampo-amygdalien afin d\u2019isoler l\u2019origine des d\u00e9ficits. Nous testerons en particulier l\u2019hypoth\u00e8se selon laquelle l’inhibition de la neurogen\u00e8se adulte hippocampique li\u00e9e \u00e0 l\u2019hyperactivit\u00e9 de l\u2019axe du stress serait au c\u0153ur des m\u00e9canismes physiopathologiques et pourrait \u00eatre \u00e0 l\u2019origine d\u2019un dysfonctionnement de l’ensemble du r\u00e9seau cortico-hippocampo-amygdalien, entrainant l\u2019apparition des troubles mentaux. Nous esp\u00e9rons donc ainsi isoler des marqueurs pr\u00e9dictifs et des cibles th\u00e9rapeutiques potentielles des pathologies mentales li\u00e9es \u00e0 l\u2019exposition au stress d\u00e9veloppemental.<\/p>\n

Lucile Capuron (Nutrineuro)<\/h3>\n

Projet :<\/strong> Effets combin\u00e9s du stress pr\u00e9coce et de l’ob\u00e9sit\u00e9 li\u00e9e aux habitudes alimentaires \u00e0 l’\u00e2ge adulte dans le d\u00e9veloppement de la d\u00e9pression : caract\u00e9risation ph\u00e9notyique et \u00e9valuation m\u00e9canistique<\/p>\n

Environmental factors play a strong role in the development of major depression (MD), one of the most prevalent and disabling disorders worldwide. As such, we and others showed that obesity, resulting primarily from dietary habits, is associated with an increased prevalence of MD. Our preliminary findings suggest that adiposity-driven inflammatory processes contribute to this effect, notably through alterations in dopamine (DA) metabolism and function, consistent with the well-known role of inflammation in the pathophysiology of MD. Not all obese subjects, however, develop MD suggesting that inflammation per se is not sufficient but acts in conjunction with other factors to induce MD. Our recent data point to early life stress (ELS) as a potential determining factor.
\nThe objectives of the project are to assess the synergistic effects of ELS and adult obesity on depressive morbidity and to determine the causal role of DA dysfunction in mediating these effects, through alterations in GCH1\/BH4 enzymatic pathway. For this purpose, the project will adopt a multidisciplinary and translational approach and will combine epidemiological and clinical studies to assess the respective and combined contribution of ELS and adult obesity on inflammation driven DA-related alterations and MD clinical dimensions, together with preclinical investigations to unravel the causal mechanisms. It will benefit from the coordinated efforts of researchers with renowned expertise in epidemiology, immunopsychiatry and preclinical basic neuroscience. Down the road, this project will provide a better definition of the mechanisms and factors contributing to depressive morbidity and will allow identifying novel biomarkers with relevance to specific symptom dimensions, which is crucial for the development of personalized medicine strategies. Moreover, by dissecting the causal molecular mechanisms at play, this project will unravel putative targets for new therapeutic strategies for MD.<\/p>\n

Erwan Bezard (IMN) \/ co-PI<\/h3>\n

Demandeur: Laurence HUC – INRAe Toulouse<\/span> <\/strong><\/p>\n

Projet :<\/strong> Approche EcoHealth pour l\u2019\u00e9valuation de l\u2019usage des fongicides SDHI: exposome et dangers pour la sant\u00e9 humaine<\/span><\/p>\n

<\/div>\n
\n
Succinate deshydrogenase inhibitors (SDHI) constitute a family of fungicides that has been increasingly used in the past five years. They target the succinate dehydrogenase, a crucial enzyme that participates to cell respiration in mitochondria of most of living cells. Inactivation of SDH in human is involved in many<\/div>\n
diseases including neurodegenerative and renal diseases and cancers. Our first work demonstrated that SDHI were able to inhibit the SDH of human, worm and bee. The EcohealthSDHI project proposes an interdisciplinary approach aiming at:<\/div>\n
1) setting up quantitative and sensitive methods of detection of SDHI and metabolites to evaluate the environmental exposome<\/div>\n
2) quantifying the levels of SDHI in farmers and in general population in urines for human exposome, to correlate with chronic diseases incidences<\/div>\n
3) characterizing toxicity of SDHI and the consequences of the exposure to health (Parkinson, renal and intestinal diseases) with the hypothesis that they would modulate mitochondria physiology, reprogram metabolism and alter epigenetic methylations. We will focus on humans, rodents and fishes, with in vivo and in vitro approaches.<\/div>\n
4) Improving regulatory framework by taking take advantage of the SDHI case study to improve risk assessment based on interdisciplinarity and co-construction of knowledge. This project, whose data will be in open-access, will be concluded with a symposium with the general public, stakeholders and politicians concerned with the issues involved in the use of SDHI<\/div>\n<\/div>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

F\u00e9licitations aux laur\u00e9at(e)s !<\/p>\n","protected":false},"author":108,"featured_media":126396,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[91,133],"tags":[],"class_list":["post-126434","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-awards","category-fundings"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126434","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=126434"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126434\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/126396"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=126434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=126434"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=126434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}