{"id":126147,"date":"2020-10-09T14:50:51","date_gmt":"2020-10-09T12:50:51","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=126147"},"modified":"2020-10-09T15:20:55","modified_gmt":"2020-10-09T13:20:55","slug":"michel-thiebaut-de-schotten-et-al-in-nature-communication","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/michel-thiebaut-de-schotten-et-al-in-nature-communication\/","title":{"rendered":"Michel Thiebaut de Schotten et al in Nature Communication<\/em>"},"content":{"rendered":"

Voir le communiqu\u00e9 sur le site du CNRS (in french)<\/a><\/p>\n

\"\"<\/a>
Credit : Michel Thiebaut de Schotten<\/figcaption><\/figure>\n

A collaborative work between a French CNRS research team led by Michel Thiebaut de Schotten and a British UCL team led by Parashkev Nachev has just produced the very first functional atlas of human cerebral white matter, mapping more than 500 brain functions. This is a major conceptual innovation\u00a0in human neuroscience research that will allow the study of new brain functions on the basis of their connectivity. It\u00a0could\u00a0also be a valuable medical tool in identifying stroke injuries and the disruption of functional circuits they cause.<\/p>\n

We commonly call gray matter the outer layer of the brain (or cerebral cortex) devoted to the most integrated cerebral functions,\u00a0such as\u00a0visuospatial, language or memory skills. The cerebral cortex is constituted of the cell bodies of neurons,\u00a0giving it its eponymous colour.\u00a0Just as good communication between individuals is essential for the\u00a0functioning of a society, good communication between cortical regions is essential for\u00a0brain function. In the brain, communication is\u00a0enabled\u00a0by\u00a0tract-like\u00a0extensions of neurons# — axons — which group together in bundles to connect the different brain regions together,\u00a0some of which reaching a length\u00a0over\u00a020 cm. True communication channels,\u00a0in\u00a0connecting the functions of several brain regions, these white matter bundles allow the creation of new, more complex\u00a0functions\u00a0similarly to a\u00a0group of letters that makes a full\u00a0word with a\u00a0specific meaning.<\/p>\n

For a long time, research in human neuroscience has focused on the study of brain functions associated with cortical regions. Brain imaging techniques developed in the early 2000s, such as functional MRI for example, have made it possible to map brain functions (language, logic, memory, etc.) on the surface of the cortex. But we can clearly see the limits of\u00a0this approach, which\u00a0does\u00a0not allow us to understand the relationships between different cortical regions\u00a0involved in\u00a0the same function. With the advent of new imaging techniques making it possible to model white matter\u00a0tracts\u00a0(for the past ten years or so), neuroscience is entering a new era where the anatomical support of brain functions is no longer considered only as a collection of regions on the surface of the brain, but as a network of interconnected nodes communicating with each other. This study, based on\u00a0one of\u00a0the largest collection of brain damaged by stroke (1333 patients) combined with the most comprehensive meta-analysis database in neuroimaging (Neurosynth) and the best current white matter mapping derived from the “Human Connectome 7T \u201d,\u00a0has\u00a0produced the first-ever functional white matter atlas, which alone maps more than 500 different functions in the brain. This is a\u00a0major\u00a0conceptual and epistemological\u00a0advance\u00a0in human neuroscience since cerebral functions are no longer defined a priori and sought only in the cerebral cortex, but they now emerge from the in-depth analysis of white matter networks conceived as functional territories defined by their\u00a0connectivity. By placing itself at the interface of basic research and medical research, this atlas promises to be an essential tool for exploring new brain functions and their circuits as well as for identifying typical stroke lesions which interrupt the circuits of the brain. white matter for given functional activation networks<\/p>\n

\"Coupes<\/a>
Coupes axiales de l\u2019Atlas fonctionnel de la substance blanche c\u00e9r\u00e9brale humaine. Cr\u00e9dit : Michel Thiebaut de Schotten<\/figcaption><\/figure>\n

More details<\/h3>\n

Brain disconnections link structural connectivity with function and behaviour<\/span><\/a>
\nThiebaut de Schotten\u00a0M, Foulon\u00a0 <\/sup>C, Nachev P
\nNature Communications 9 Oct 2020.
\nhttps:\/\/doi.org\/10.1038\/s41467-020-18920-9<\/p>\n

* BCBtoolkit (http:\/\/toolkit.bcblab.com<\/a>)<\/p>\n

Contact
\n<\/strong><\/h3>\n

\u00a0<\/strong>Michel Thiebaut de Schotten
\n<\/strong> CNRS
\nTeam leader: Groupe d’Imagerie Neurofonctionnelle (GIN) \/ IMN<\/strong>
\nmichel.thiebaut@gmail.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Le premier atlas de la fonction des connexions c\u00e9r\u00e9brales<\/p>\n","protected":false},"author":108,"featured_media":126144,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71,140],"tags":[],"class_list":["post-126147","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en","category-for-all"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=126147"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/126147\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/126144"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=126147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=126147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=126147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}