{"id":125801,"date":"2020-09-29T22:41:27","date_gmt":"2020-09-29T20:41:27","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=125801"},"modified":"2020-09-30T09:20:52","modified_gmt":"2020-09-30T07:20:52","slug":"e-ducrouneau-et-al-in-molecular-psychiatry","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/e-ducrouneau-et-al-in-molecular-psychiatry\/","title":{"rendered":"Eva Ducourneau et al. in Molecular Psychiatry<\/em>"},"content":{"rendered":"

(A <\/b>Study<\/b> from<\/b> Desmedt\u2019s<\/b> team in collaboration <\/b>with<\/b> PV Piazza & <\/b>Lundbeck<\/b> Lab.)<\/b><\/p>\n

Comment<\/h3>\n

The paper shows (in collaboration with Lundbeck Laboratory) that acute administration of brexpiprazole, a new antipsychotic drug with pro-cognitive effects in rodents, (0.3 mg\/kg) 7 days\u2019 post-trauma persistently prevents the expression of PTSD-like memory in mice, while promoting normal fear memory. Specifically, It specifically blocks the emotional hypermnesia of PTSD<\/em> while enhancing (with superior efficacy when compared to <\/em>diazepam, prazosin and escitalopram) <\/em>memory for the traumatic context<\/em>, which is impaired in PTSD. Moreover, this treatment also normalizes most of the alterations in the hippocampal-amygdalar network activation associated with PTSD-like memory. These preclinical data indicate that brexpiprazole could represent a new pharmacological treatment of PTSD promoting the normalization of traumatic memory.<\/p>\n

Reference<\/h3>\n

Ducourneau E.G., Guette C., Perrot D<\/u>., Mondesir M., Mombereau C., Arnt J. Desmedt* A<\/u>. and Piazza* P.V. Brexpiprazole blocks Posttraumatic stress disorder-like memory while promoting normal fear memory. Molecular Psychiatry<\/em><\/strong>. 2020 Aug 19.
\n*co-last authorship.<\/p>\n

doi: 10.1038\/s41380-020-0852-z<\/a><\/p>\n

First author<\/h3>\n

Eva Ducourneau<\/strong><\/a>
\nTeam Marighetto\/Desmedt
\n(“Pathophysiology of declarative memory”)<\/a><\/p>\n

Contact<\/h3>\n
\"\"
A. Desmedt<\/figcaption><\/figure>\n

Aline Desmedt<\/strong><\/a>
\nTeam Marighetto\/Desmedt
\n(“Pathophysiology of declarative memory”)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Brexpiprazole blocks Posttraumatic stress disorder-like memory while promoting normal fear memory.<\/p>\n","protected":false},"author":108,"featured_media":125803,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71,140,215],"tags":[],"class_list":["post-125801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en","category-for-all","category-publications"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/125801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=125801"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/125801\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/125803"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=125801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=125801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=125801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}