{"id":117564,"date":"2020-03-03T17:10:20","date_gmt":"2020-03-03T16:10:20","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=117564"},"modified":"2020-03-31T10:03:28","modified_gmt":"2020-03-31T08:03:28","slug":"aude-panatier-in-cell-metabolism","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/aude-panatier-in-cell-metabolism\/","title":{"rendered":"Aude Panatier in Cell Metabolism<\/em>"},"content":{"rendered":"

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer\u2019s Disease.<\/strong> Juliette Le Douce*, Marianne Maugard*, Julien Veran*, Marco Matos*, Pierrick J\u00e9go+<\/sup>, Pierre-Antoine Vigneron+<\/sup>, Emilie Faivre+<\/sup>, Xavier Toussay,Michel Vandenberghe, Ya\u00ebl Balbastre, Juliette Piquet, Elvire Guiot, Nguyet Thuy Tran, Myriam Taverna, St\u00e9phane Marinesco, Ayumi Koyanagi, Shigeki Furuya, Myl\u00e8ne Gaudin-Guerif, S\u00e9bastien Goutal, Aur\u00e9lie Ghettas, Alain Pruvost, Alexis-Pierre Bemelmans, Marie-Claude Gaillard, Karine Cambon, Lev Stimmer, V\u00e9ronique Sazdovitch, Charles Duyckaerts, Graham Knott, Anne-Sophie H\u00e9rard, Thierry Delzescaux, Philippe Hantraye, Emmanuel Brouillet, Bruno Cauli, St\u00e9phane H.R. Oliet, Aude Panatier#<\/sup> et Gilles Bonvento#<\/sup>. Cell Metabolism, 3 March 2020.
\nDOI : 10.1016\/j.cmet.2020.02.004<\/p>\n

*<\/sup>co-first autors
\n+<\/sup>equal contribution
\n#<\/sup>These authors jointly supervised this work<\/p>\n

\n

Proper brain functioning relies on the close metabolic and synaptic interplay between neurons and astrocytes. Interestingly, the early stage of Alzheimer’s disease is associated with a decrease in brain metabolism and deficits in synaptic functions that are believed to underlie cognitive decline. However, whether there is a causal link between these processes remained unknown.<\/p>\n

The consumption of glucose by astrocytes leads to the production of various metabolites including L-serine, a precursor of D-serine, the endogenous co-agonist of synaptic NMDA receptor that is essential for long-term synaptic plasticity and memory. Thanks to a collaboration with the group of Gilles Bonvento (CNRS-CEA-University of Paris-Saclay) Aude Panatier and St\u00e9phane Oliet (Neurocentre Magendie) show in a mouse model of Alzheimer’s disease that a decrease in glucose consumption by astrocytes leads to a reduction in the production of L-serine and, consequently, in D-serine supply. As a result, synaptic NMDA receptors activity is decreased, thereby impairing neuronal plasticity and memory. Importantly, such early cognitive deficits can be fully rescued by L-serine food supplementation.<\/p>\n

The identification of the major role played by a glucose metabolite, L-serine, at an early stage of Alzheimer\u2019s disease and the success of a nutritional supplementation opens the way to new therapeutic strategies in this neurodegenerative pathology.<\/p>\n

\"\"<\/a><\/p>\n

\n

See the comment and press release in french<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer\u2019s Disease.<\/p>\n","protected":false},"author":108,"featured_media":117572,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71,1],"tags":[],"class_list":["post-117564","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en","category-news-neurocampus"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/117564","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=117564"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/117564\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/117572"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=117564"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=117564"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=117564"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}