{"id":112708,"date":"2019-10-31T14:59:53","date_gmt":"2019-10-31T13:59:53","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=112708"},"modified":"2019-10-31T15:17:55","modified_gmt":"2019-10-31T14:17:55","slug":"jerome-badaut-laureate-of-the-national-institute-of-health","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/jerome-badaut-laureate-of-the-national-institute-of-health\/","title":{"rendered":"J\u00e9r\u00f4me Badaut laureate of the National Institute of Health"},"content":{"rendered":"
\"\"<\/a>
J\u00e9r\u00f4me Badaut<\/figcaption><\/figure>\n

J\u00e9r\u00f4me Badaut<\/a><\/strong> (BMI, INCIA) is laureate of an R21 funding from the National Institute of Neuronal Disorders and Stroke (NINDS – National Institute of Health, USA<\/a>) in co-PI with Dr Bix<\/strong> (Neuroscience department, Tulane University School of Medicine ; New Orleans, USA) for a collaborative project called : “Perlecan therapy for white matter and cognitive impairment in closed head injury with long-term dysfunction (CHILD)<\/em>“.<\/strong><\/p>\n

About the project<\/h3>\n

Several clinical studies have shown that TBI as a risk factor for neurodegenerative diseases. It has been recently illustrated by the renct publication from Dr Macay and collaborators in the\u00a0New England Journal of Medicine<\/i>\u00a0(October 21, 2019; DOI: 10.1056\/NEJMoa1908483): soccer professional players suffer of higher mortality than the rest of the population due to neurodegenerative disease, possibly caused by chronic traumatic encephalopathy!<\/p>\n

It is very important to highlight that mild juvenile traumatic brain injury (jmTBI) represents more than 80% of Emergency visits. It represents a major public health issue, that is associated with a risk factor for cognitive decline and dementia. Therefore, it is critical to have a better understanding of the long-term changes in order to accurately develop new treatments to prevent these long-term cognitive sequelae. Drs Badaut and Bix proposed a unique research project that will characterize the neurovascular dysfunction and extracellular matrix (ECM) degradation that occurs in white matter (WM) after jmTBI. They will test whether the neuroprotective and angiogenic C-terminal protein fragment domain V (DV) of the vascular ECM heparan sulfate proteoglycan perlecan, is acutely generated and plays a significant, potentially beneficial role to WM\u2019s response to- and long-term cognitive consequences of jmTBI. Positive outcome from this project will give unique opportunity to develop new therapeutical approach.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Co-PI with Dr. Bix (New Orleans)<\/p>\n","protected":false},"author":108,"featured_media":112714,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[91],"tags":[],"class_list":["post-112708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-awards"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/112708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=112708"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/112708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/112714"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=112708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=112708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=112708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}