{"id":107187,"date":"2019-05-08T14:20:29","date_gmt":"2019-05-08T12:20:29","guid":{"rendered":"https:\/\/www.bordeaux-neurocampus.fr\/?p=107187"},"modified":"2019-05-08T14:23:10","modified_gmt":"2019-05-08T12:23:10","slug":"m-wolff-et-al-in-elife","status":"publish","type":"post","link":"https:\/\/www.bordeaux-neurocampus.fr\/en\/m-wolff-et-al-in-elife\/","title":{"rendered":"M. Wolff et al in <em>Elife<\/em>"},"content":{"rendered":"<p><a href=\"https:\/\/elifesciences.org\/articles\/46187\"><strong>A thalamocortical circuit for updating action-outcome associations.<\/strong><\/a><br \/>\nFresno V, Parkes SL, Faug\u00e8re A, Coutureau E, Wolff M.<br \/>\n<a href=\"https:\/\/elifesciences.org\/articles\/46187\">Elife. 2019 Apr 23;8. pii: e46187. doi: 10.7554\/eLife.46187.<\/a><\/p>\n<hr \/>\n<p><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2019\/05\/wolff-avril2019-fondblanc.jpg\" rel=\"lightbox[107187]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-107193 \" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2019\/05\/wolff-avril2019-fondblanc-360x222.jpg\" alt=\"A thalamocortical circuit for updating action-outcome associations.\" width=\"315\" height=\"194\" srcset=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2019\/05\/wolff-avril2019-fondblanc-360x222.jpg 360w, https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2019\/05\/wolff-avril2019-fondblanc.jpg 662w\" sizes=\"auto, (max-width: 315px) 100vw, 315px\" \/><\/a>The ability to flexibly use knowledge is one cardinal feature of goal-directed behaviors. The <a href=\"http:\/\/www.incia.u-bordeaux1.fr\/spip.php?article357\">DECAD team<\/a> recently showed that <a href=\"http:\/\/www.incia.u-bordeaux1.fr\/spip.php?article605\">thalamocortical and corticothalamic pathways connecting the medial prefrontal cortex and the mediodorsal thalamus (MD) contribute to adaptive decision-making<\/a> (<strong><a href=\"http:\/\/www.incia.u-bordeaux1.fr\/%5b-%3ehttps:\/elifesciences.org\/articles\/32517\">Alcaraz et al., 2018<\/a><\/strong><strong>]<\/strong>). In this study, the team examined the impact of disconnecting the MD from its other main cortical target, the orbitofrontal cortex (OFC) in a task assessing outcome devaluation after initial instrumental training and after reversal of action-outcome contingencies. Crossed MD and OFC lesions did not impair instrumental performance. In sharp contrast, disconnecting the OFC from its other main thalamic afferent, the submedius nucleus, produced a specific impairment in adaptive responding following action-outcome reversal. Altogether, this suggests that multiple thalamocortical circuits may act synergistically to achieve behaviorally relevant functions and confirm <a href=\"http:\/\/www.incia.u-bordeaux1.fr\/spip.php?article654\">a prominent role for the cognitive thalamus in shaping mental representations<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A thalamocortical circuit for updating action-outcome associations<\/p>\n","protected":false},"author":108,"featured_media":107190,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71,1],"tags":[],"class_list":["post-107187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-highlight-en","category-news-neurocampus"],"_links":{"self":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/107187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/comments?post=107187"}],"version-history":[{"count":0,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/posts\/107187\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media\/107190"}],"wp:attachment":[{"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/media?parent=107187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/categories?post=107187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/wp\/v2\/tags?post=107187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}