{"id":170018,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=170018","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=170018"],"author":"108","status":"publish","date":"2024-03-14 12:03:38","date_utc":"2024-03-14 11:03:38","modified":"2024-04-03 16:06:55","modified_utc":"2024-04-03 14:06:55","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminar-giuseppe-gangarossa\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/170018","title":"Seminar – Giuseppe Gangarossa","description":"

Venue: CGFB<\/strong><\/p>\n

\n

\"\"Giuseppe <\/strong>Gangarossa
\n<\/strong>Professor of Neurobiology of Homeostasis
\nUniversit\u00e9 Paris Cit\u00e9<\/p>\n

Invited by Victor Jouque and Daniela Cota (Magendie)<\/p>\n

Title<\/h3>\n

The paraventricular thalamus: a new player in the control of feeding behaviours and energy balance<\/b><\/p>\n

Abstract<\/h3>\n

The paraventricular thalamus (PVT) has recently emerged as a critical hub involved in the regulation of cognitive processes but also in the integration of homeostatic and visceral signals, thus controlling adaptive and food-seeking behavioural responses. However, despite growing evidence, the neural mechanisms by which the PVT gates feeding, energy balance and nutrients partitioning remain largely unknown.<\/p>\n

Here, we show that catecholaminergic projections from the hindbrain to the PVT and a specific subpopulation of PVT-neurons, notably those expressing the dopamine D2 receptors, promptly and bidirectionally gate feeding behaviours, body homeostasis and energy balance, thereby contributing to the control of energy-related adaptive responses in both physiological and obesogenic contexts. In addition, by combining complementary cutting-edge strategies (cell-type specific chemogenetics,\u00a0ex vivo<\/i>\u00a0and\u00a0in vivo<\/i>\u00a0neuronal dynamics) to functional behavioural and metabolic readouts, we describe PVT D2R-neurons as gatekeepers of hunger and satiety.<\/p>\n

\n

These results may lead to a new understanding of unconventional brain circuits involved in food-related disorders and may provide new therapeutic solutions to counterbalance obesity-associated dysfunctions.<\/p>\n

Recent publications<\/h3>\n

Castel et al., 2024 (Mol Psychiatry, PMID: 38361126)<\/a>
\nDumont et al., 2022 (J Physiol, PMID: 35648134)<\/a>
\nBerland et al., 2022 (Mol Psychiatry, PMID: 35075269)<\/a>
\nBerland et al., 2021 (Trends Endocrinol Metab, PMID: 34148784)<\/a>
\nBerland et al., 2020 (Cell Metab, PMID: 32142669)<\/a><\/p>\n<\/div>","excerpt":"

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