{"id":152817,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=152817","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=152817"],"author":"108","status":"publish","date":"2022-11-17 09:53:57","date_utc":"2022-11-17 08:53:57","modified":"2022-11-17 09:57:05","modified_utc":"2022-11-17 08:57:05","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-maud-martinat\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/152817","title":"Thesis defense – <\/span>Maud Martinat","description":"

Venue: to be confirmed<\/p>\n

Defense in french<\/p>\n

\n

Thesis supervisor: Sophie Lay\u00e9 (NutriNeuro)<\/p>\n

Title<\/h3>\n

Om\u00e9ga 3 et troubles de l’humeur : m\u00e9canismes d’action neuroprotecteurs (Omega 3 and mood disorders, study of neuroprotective actions mechanisms)<\/p>\n

R\u00e9sum\u00e9<\/h3>\n

T<\/span>he brain is rich in polyunsaturated fatty acids (PUFA) whose long chains, such as docosahexaenoic<\/span> acid (DHA) and ecosapentaenoic acid (EPA) from omega 3 (n<\/span>–<\/span>3), accumulate during development. Their<\/span> precursors are not synthesized de novo by mammals and must<\/span> be provided by food. However, it has<\/span> been shown that an unbalanced and deficient maternal dietary intake of n<\/span>–<\/span>3 PUFAs induces cognitive<\/span>
and electrophysiological alterations in infants and in mouse models of nutritional deficiency.<\/span><\/span><\/span><\/p>\n

We are interested in the<\/span> impact of a nutritional intervention during development and how a diet<\/span> unbalanced in n<\/span>–<\/span>3 PUFA alters neural networks and cognition, by studying the molecular mechanisms<\/span> and taking into account the gender. To this end, different models are used: 1) mice ar<\/span>e deficient in <\/span>PUFAs during development and then exposed to a diet rich in n<\/span>–<\/span>3 PUFAs at weaning; 2) to develop a <\/span><\/span>local deficiency model by viral injection blocking the expression of the elongase ELOVL2 (involved in<\/span> the synthesis of long<\/span>–<\/span>chain PUFAs) in ast<\/span>rocytes to assess the impact on the properties of the<\/span> surrounding neurons<\/span>.<\/span><\/span><\/p>\n

Our results suggest that a change in nutritional status from deficiency to a diet rich in n<\/span>–<\/span>3 PUFA at<\/span> weaning restores 1) long<\/span>–<\/span>term synaptic plasticity in the hippocampus in males<\/span> and females, 2)<\/span> cognition as well as fatty acid levels in the brain but in a differential manner between the two sexes. <\/span><\/span>In the second part of the results, a local variation of PUFA synthesis in the astrocyte modifies the<\/span> excitability of neurons without mod<\/span>ifying the levels of fatty acids in the brain structure while modifying<\/span> some criteria of emotional behavior.<\/span><\/span><\/span><\/span><\/p>\n


Key words<\/span><\/strong>:<\/strong> PUFA, developpment, cognition, neuroprotection<\/span><\/span><\/p>\n

Jury<\/h3>\n

Pr M\u00e9lanie Plourde<\/strong>, Professeure, Universit\u00e9 de Sherbrooke, Qu\u00e9bec, Canada, Rapportrice<\/strong><\/p>\n

Dr Pascale Chavis<\/strong>, Directrice de Recherche, Inmed, Marseille, France,\u00a0 \u00a0Rapportice<\/strong><\/p>\n

Dr Niyazi Acar<\/strong>, Directeur de Recherche, INRAE, Dijon, France,\u00a0Examinateur<\/strong><\/p>\n

Pr Fr\u00e9d\u00e9ric Calon<\/strong>, Professeur, Universit\u00e9 de Laval, Canada, Pr\u00e9sident, Examinateur<\/strong><\/p>\n

Pr Richard Bazinet<\/strong>, Professeur Associ\u00e9, Universit\u00e9 de Toronto, Canada,\u00a0Co-directeur<\/strong><\/p>\n

Dr Sophie Lay\u00e9<\/strong>, Directrice de Recherche, INRAE, Bordeaux, France,\u00a0Directrice \u00a0\u00a0<\/strong><\/p>","excerpt":"

Omega 3 and mood disorders, study of neuroprotective actions mechanisms<\/p>","slug":"thesis-defense-maud-martinat","image":false,"all_day":false,"start_date":"2022-12-16 14:00:00","start_date_details":{"year":"2022","month":"12","day":"16","hour":"14","minutes":"00","seconds":"00"},"end_date":"2022-12-16 14:00:00","end_date_details":{"year":"2022","month":"12","day":"16","hour":"14","minutes":"00","seconds":"00"},"utc_start_date":"2022-12-16 13:00:00","utc_start_date_details":{"year":"2022","month":"12","day":"16","hour":"13","minutes":"00","seconds":"00"},"utc_end_date":"2022-12-16 13:00:00","utc_end_date_details":{"year":"2022","month":"12","day":"16","hour":"13","minutes":"00","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CET","cost":"","cost_details":{"currency_symbol":"","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Thesis","slug":"theses-en","term_group":0,"term_taxonomy_id":187,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":254,"filter":"raw","id":187,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/187","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"<span>Thesis defense – <\/span>Maud Martinat","description":"<p>Omega 3 and mood disorders, study of neuroprotective actions mechanisms<\/p>\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-maud-martinat\/","startDate":"2022-12-16T14:00:00+01:00","endDate":"2022-12-16T14:00:00+01:00","performer":"Organization"}}