{"id":145748,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=145748","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=145748"],"author":"108","status":"publish","date":"2022-03-21 11:35:38","date_utc":"2022-03-21 10:35:38","modified":"2022-03-21 11:43:25","modified_utc":"2022-03-21 10:43:25","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/impromptu-seminar-julien-courtin\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/145748","title":"Impromptu seminar – Julien Courtin","description":"
\"\"<\/a>
\nJulien Courtin<\/strong>
\nPost-doctoral researcherFriedrich Miescher Institute, Basel<\/p>\n

https:\/\/scholar.google.nl\/citations?user=AIXtCZUAAAAJ&hl=en<\/a><\/p>\n<\/div>\n

Venue: Centre Broca<\/p>\n

\n

Title<\/h3>\n

Amygdala in action<\/strong><\/em><\/p>\n

Abstract<\/h3>\n
Acting to achieve goals depends on the ability to motivate specific behaviors. By definition, <\/span>instrumental goal-directed actions are oriented toward specific outcomes and are sensitive to <\/span>variations in outcome value and action-outcome contingency. However, the underlying neuronal <\/span>mechanisms that encode and maintain such parameters are poorly understood. Here we used <\/span>calcium imaging and optogenetic manipulations in basolateral amygdala of freely moving mice <\/span>performing non-cued, self-paced instrumental goal-directed actions to receive and consume <\/span>rewards. We show that distinct neuronal activity patterns sequentially represent the entire actionconsumption <\/span>behavioral sequence. Whereas action-associated patterns integrate the identity, <\/span>value and expectancy of pursued goals, consumption-associated patterns reflect the identity and <\/span>value of experienced outcomes. Thus, the interplay between these patterns allows the <\/span>maintenance of specific motivational states necessary to adaptively direct behavior toward <\/span>prospective rewards. Finally, by tracking the neuronal activity of same neurons over a multiphase <\/span>behavioral task we show that such motivational states allow the transfer and reinstatement <\/span>of specific memories.<\/span><\/div>\n
\n

Invited by Cyril Herry (Neurocentre Magendie)<\/strong><\/p>","excerpt":"

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