Dynamic study of the generation of beta oscillations in Parkinson’s disease<\/p>\n
Defended: Decembre 9, 2016<\/p>\n
Supervisor : <\/strong>Thomas Boraud, team leader :\u00a0Physiology and pathophysiology of executive functions \/\u00a0CNRS UMR 5293, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives (IMN), Universit\u00e9 de Bordeaux . The basal-ganglia (BG) form a complex loop with the cortex and the thalamus that is involved in action selection and movement control.<\/strong> Synchronized oscillatory activities in basal-ganglia neuronal circuits have been proposed to play a key role in coordinating information flow within this neuronal network. If synchronized oscillatory activities are important for normal motor function, their dysregulation in space and time could be pathological. Indeed, in Parkinson\u2019s disease (PD), many studies have reported an abnormal increase in the expression level of neuronal oscillations contain in the beta (\u03b2) frequency range (15-30 Hz).<\/p>\n These abnormal \u03b2 oscillations have been correlated with two mains symptoms of PD: akinesia\/bradykinesia. However, which BG neuronal circuits generate those abnormal \u03b2 oscillations, and whether they play a causal role in PD motor dysfunction is not known. The subthalamic nucleus (STN) is a key nucleus in BG that receives converging inputs from the motor cortex, the parafascicular thalamic nucleus and the globus pallidus. Here, we used a rat model of PD combined with in vivo electrophysiological recordings and optogenetic silencing to investigate how selective manipulation of STN inputs causally influence BG network dynamic.<\/p>\n Our data highlight the causal role of the globus pallidus in the generation and propagation mechanisms of abnormal \u03b2-oscillations.<\/p>\n Key-words:<\/strong> Parkinson\u2019s disease, \u03b2 oscillation (Beta), basal ganglia, globus pallidus, motor cortex, parafascicular thalamic nucleus, optogenetics, in vivo electrophysiology, juxtacellular labeling.<\/em><\/p>\n Publications<\/em><\/strong> Inhibiting Lateral Habenula Improves L-DOPA-induced Dyskinesia. Biological Psychiatry, 79(5), 345\u2013353.<\/em><\/p>\n Catherine LE MOINE<\/strong> St\u00e9phane CHARPIER<\/strong> (Rapporteur), Professeur des Universit\u00e9s, Universit\u00e9 de Paris VI, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re.<\/p>\n Bertrand DEGOS<\/strong> (Rapporteur), MD PhD, PH, Centre Interdisciplinaire de Recherche en Biologie.<\/p>\n Corinne BEURRIER,<\/strong>CR,Institut de Biologie du D\u00e9veloppement de Marseille.<\/p>\n Nicolas MALLET, CR,<\/strong> Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n Thomas Boraud, DR Thomas Boraud<\/strong>
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\n de la Crompe B, Boraud T and Mallet N. Circuit mechanism of beta oscillation expression in basal ganglia (in preparation) Bastide, M. F., de la Crompe, B., Doudnikoff, E., Fernagut, PO., Gross, C. E., Mallet, N., Boraud T, B\u00e9zard, E. (2014).<\/em><\/p>\n
\nJury<\/h3>\n
\n(Pr\u00e9sident),DR, Universit\u00e9 de Bordeaux, Institut de Neurosciences Cognitives et Int\u00e9gratives d’Aquitaine.<\/em><\/p>\n
\n<\/strong>CNRS,\u00a0Directeur de th\u00e8se
\nIMN, Universit\u00e9 de Bordeaux<\/p>\n
\nPhD Supervisor<\/h3>\n
\nTeam leader : Physiology and pathophysiology of executive functions \/ CNRS UMR 5293, Institut des Maladies Neurod\u00e9g\u00e9n\u00e9ratives (IMN), Universit\u00e9 de Bordeaux<\/em><\/p>\n