{"id":135324,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=135324","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=135324"],"author":"108","status":"publish","date":"2021-05-26 10:58:13","date_utc":"2021-05-26 08:58:13","modified":"2021-10-14 11:29:22","modified_utc":"2021-10-14 09:29:22","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/phd-seminar-29october-2021\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/135324","title":"Monthly conference (PhD seminar) – Homaira Nawabi","description":"

[vc_row][vc_column width=”2\/3″][vc_column_text]Centre Broca Nouvelle-Aquitaine<\/p>\n

\n

<\/span>Axon Guidance during mature CNS regeneration<\/span><\/span><\/em><\/p>\n

Abstract<\/h3>\n

Mature neurons from the central nervous system<\/span> are not able to regenerate after an insult.\u00a0 <\/span>Therefore, patients have to bear motor and or cognitive disabilities for the rest of their li<\/span>v<\/span>es <\/span>as no treatment is available.<\/span>
Many efforts have been deployed to <\/span>understand this discrepancy. For over 20<\/span> years it has <\/span>been thought that the CNS environment was the main cause of this lack of regeneration. <\/span>Indeed, after CNS injury, myelin debris release and glia scar formation act as a chemical <\/span>and physical barrier for <\/span>axon outgrowth. Surprisingly their modulation in vivo did not unlock <\/span>CNS repair. Since <\/span>2008, it has been shown that neurons themselves <\/span>loose<\/span> the ability to <\/span>regenerate over the course of development. <\/span> We showed that t<\/span>his capacity is further <\/span>decreased by the <\/span>injury itself. <\/span>Thus, <\/span>by <\/span>modulating the neuronal intrinsic molecular pathways <\/span>we are now able to induce long distance regeneration. However, another unexpected <\/span>roadblock stands on the way to achieve functional recovery: regenerating axons present <\/span>strong guida<\/span>nce defect<\/span>s<\/span> that counteract any attempt to build a functional circuit. By using <\/span>the model of the optic nerve and the visual system our lab aims to understand axon guidance <\/span>mechanism in mature CNS during regeneration<\/span>.<\/span><\/p>\n

Selected publications<\/h3>\n

1<\/span>–<\/span> Vilallongue<\/span> N<\/span>, Schaeffer<\/span> J,<\/span> Hesse AM, Delpech C, Paccard A Cout\u00e9 Y, Belin S, <\/span>Nawabi H<\/span>. <\/span>Axon guidance <\/span>modalities <\/span> in <\/span> CNS <\/span> regeneration <\/span> revealed <\/span> by <\/span> quantitative <\/span> proteomic <\/span> analysis<\/span>. <\/span> BioRxive <\/span> 2021<\/span> (<\/span>doi:<\/span> https:\/\/doi.org\/10.1101\/2021.03.26.437129<\/span>)<\/span><\/p>\n

2<\/span>–<\/span> SchaefferJ<\/span>*<\/span>, <\/span>Delpech C*, <\/span>Albert F, Belin S, <\/span>Nawabi<\/span> H<\/span>. <\/span>Adult mouse retina explants: an ex vivo window to <\/span>explore central nervous system diseases<\/span>.<\/span> * <\/span>co first autors; <\/span>co<\/span>–<\/span>lead. <\/span>Frontiers in Molecular Neuroscience<\/span> 2020<\/span><\/p>\n

3<\/span>–<\/span> Sonoda T, Li JY, Hayes NW, Chan JC, Okabe Y, Belin S, <\/span>Nawabi H<\/span>, Schmidt TM. <\/span>A noncanonical inhibitory <\/span>circuit dampens behavioral sensitivity to light.<\/span> Science 20<\/span>20<\/span><\/p>\n

4<\/span>–<\/span> Nawabi H<\/span>*, Belin S*, Cartoni R*, Williams PR, Wang C, Latremoli\u00e8re A, Wang X, Zhu<\/span> J, Taub DG, Fu X, Yu B, <\/span>Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z.<\/span> Doublecortin<\/span>–<\/span>Like Kinases Promote Neuronal Survival and <\/span>Induce Growth Cone Reformation via Distinct Mechanisms.<\/span> Neuron <\/span> 2015<\/span> Nov 18;88(4):704<\/span>–<\/span>19.<\/span> *<\/span>equal <\/span>contribution <\/span><\/p>\n

5<\/span>–<\/span> Belin S* <\/span>Nawabi H*<\/span>, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen <\/span>JA. <\/span>Injury<\/span>–<\/span>induced decline of intrinsic regenerative ability revealed by quantitative proteomics. <\/span>Neuron 2015 <\/span>May 20;86(4):1000<\/span>–<\/span>14.<\/span>)<\/span> *<\/span>equal contribution<\/span>. <\/span>Article <\/span>cited as<\/span> Editor\u2019s choice in <\/span>Science Signaling<\/span> 26 May 2015 <\/span>Vol.8 issue378<\/span><\/p>\n

\n

Organized by Bordeaux Neurocampus, NBA and Bordeaux Neurocampus Graduate Program<\/em><\/strong>[\/vc_column_text][vc_video link=”https:\/\/www.youtube.com\/watch?v=r4ha8fFgzk0″ title=”Remise du Grand prix 2018 Fondation NRJ – Institut de France par Daniel Choquet”][\/vc_column][vc_column width=”1\/3″][vc_column_text]\"\"<\/a><\/span><\/span><\/strong><\/p>\n

Homaira Nawabi
\n<\/span><\/span><\/strong><\/span>GIN \u2013 Grenoble, FR<\/span><\/span>
\n<\/span><\/span><\/p>\n

https:\/\/nblab.univ-grenoble-alpes.fr<\/a>[\/vc_column_text][vc_text_separator title=”Share a pizza with the speaker” i_icon_fontawesome=”fas fa-pizza-slice” i_color=”custom” color=”custom” add_icon=”true” i_custom_color=”#218e39″ accent_color=”#218e39″ el_class=”color218e39″][vc_column_text]<\/p>\n

Ph.D. students are invited to a networking event with the guest speaker around some pizzas.<\/p>\n

Deadline to register: 48h prior the event
\nRegistration form<\/strong><\/a><\/p>\n

Note: According to the legislation in vigour, you may be requested to show your sanitary pass to attend this event<\/p>\n

[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","excerpt":"

Axon Guidance during mature CNS regeneration<\/p>","slug":"phd-seminar-29october-2021","image":false,"all_day":false,"start_date":"2021-10-29 11:30:00","start_date_details":{"year":"2021","month":"10","day":"29","hour":"11","minutes":"30","seconds":"00"},"end_date":"2021-10-29 12:30:00","end_date_details":{"year":"2021","month":"10","day":"29","hour":"12","minutes":"30","seconds":"00"},"utc_start_date":"2021-10-29 09:30:00","utc_start_date_details":{"year":"2021","month":"10","day":"29","hour":"09","minutes":"30","seconds":"00"},"utc_end_date":"2021-10-29 10:30:00","utc_end_date_details":{"year":"2021","month":"10","day":"29","hour":"10","minutes":"30","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CEST","cost":"","cost_details":{"currency_symbol":"","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"For scientists","slug":"for-scientists","term_group":0,"term_taxonomy_id":301,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":769,"filter":"raw","id":301,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/301","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}},{"name":"home-event","slug":"home-event","term_group":0,"term_taxonomy_id":285,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":810,"filter":"raw","id":285,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/285","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}},{"name":"Monthly conferences","slug":"monthly-conferences","term_group":0,"term_taxonomy_id":191,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":74,"filter":"raw","id":191,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/191","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Monthly conference (PhD seminar) – Homaira Nawabi","description":"<p>Axon Guidance during mature CNS regeneration<\/p>\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/phd-seminar-29october-2021\/","startDate":"2021-10-29T11:30:00+02:00","endDate":"2021-10-29T12:30:00+02:00","performer":"Organization"}}