{"id":133047,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=133047","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=133047"],"author":"108","status":"publish","date":"2021-03-23 13:59:03","date_utc":"2021-03-23 12:59:03","modified":"2021-03-24 16:56:53","modified_utc":"2021-03-24 15:56:53","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-cynthia-alkhoury-abboud\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/133047","title":"Thesis defense – <\/span>Cynthia Alkhoury Abboud","description":"

[vc_row][vc_column width=”2\/3″][vc_column_text]Via zoom: https:\/\/u-bordeaux-fr.zoom.us\/j\/86237726350<\/a><\/p>\n

Defense in english<\/p>\n

\n

Peptidergic control of pain: modulation of descending pathways by the relaxin systems<\/strong><\/em><\/p>\n

Abstract<\/h3>\n

Chronic pain, often accompanied by anxiety and depression, is a global scourge. The modulation of pain by neuropeptides (NP) is well known at the level of primary afferents and the spinal cord. However, little data is available on their role in pain in the brain. The relaxin family includes relaxin, which is present in the central nervous system (CNS) and has antifibrotic properties, and relaxin-3, which is strictly expressed in the CNS and has anxiolytic and antidepressant effects. Our objective is to study the modulation of pain by the neuropeptides relaxin and relaxin-3 in a mouse model of persistent inflammatory pain.<\/p>\n

Our results show that not only the relaxin-3 \/ RXFP3 system, but also the relaxin \/ RXFP1 system, which is still poorly explored in the CNS, have analgesic effects in conditions of inflammatory pain. The sites of action of these peptide systems include cortical (cingulate cortex, claustrum) and subcortical (amygdala) regions that regulate descending pathways and sensory integration in the spinal cord. Our data highlight the therapeutic potential of this peptide family, whose role in pain has never been tested before.<\/p>\n

Keywords:\u00a0<\/strong>Chronic pain, amygdala, anterior cingulate cortex, relaxin, relaxin-3.<\/p>\n

Publications<\/h3>\n

Animal models of pain: Diversity and benefits.
\nAbboud C., Duveau, A., Bouali-Benazzouz, R., Mass\u00e9, K., Mattar, J., Brochoire, L., Fossat, P., Bou\u00e9-Grabot, E., Hleihel, W., and Landry, M. J Neurosci Methods (2020) 108997<\/p>\n

Analgesic effect of relaxin receptor (RXFP-1) activation on persistent inflammatory pain in mice: behavioral and neurochemical data.
\nAbboud C., Brochoire L., Drouet A., Akhter Hossain M., Hleihel W. and Landry M.
\nEn soumission<\/p>\n

Jury<\/h3>\n

Mme BERTRAND Sandrine, Professeure, Universit\u00e9 de Bordeaux-France (Pr\u00e9sidente)
\nMme SANCHEZ PEREZ Ana Maria, Professeure, Universit\u00e9 Jaume I de Castellon-Espagne (Rapportrice)
\nMme ZAKY Amira, Professeure, Universit\u00e9 d\u2019Alexandrie-Egypte (Rapportrice)
\nMme ABI FADEL Marianne, Professeure, Universit\u00e9 Saint Joseph-Liban (Examinatrice)
\nM. FARES Nassim, Professeur, Universit\u00e9 Saint Joseph-Liban (Examinateur)
\nM. MATTAR Hanna, Docteur, Universit\u00e9 de Saint Esprit Kaslik-Liban (Examinateur)
\nM. LANDRY Marc, Professeur, Universit\u00e9 de Bordeaux-France (Directeur de th\u00e8se)
\nM. HLEIHEL Walid, Professeur, Universit\u00e9 du Saint Esprit Kaslik-Liban (Co-directeur de th\u00e8se)[\/vc_column_text][\/vc_column][vc_column width=”1\/3″][vc_column_text]\"\"<\/a><\/strong><\/p>\n

Cynthia Alkhoury Abboud
\n<\/strong>Team Purinergic mediated neuroinflammation and brain disorders<\/strong>
\n<\/strong>IMN
\n<\/strong><\/p>\n

Thesis supervisors: Marc Landry and Walid Hleihel (Universit\u00e9 Saint-Esprit – Kaslik – Liban)[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","excerpt":"

Peptidergic control of pain: modulation of descending pathways by the relaxin systems<\/p>","slug":"thesis-defense-cynthia-alkhoury-abboud","image":false,"all_day":false,"start_date":"2021-03-31 09:00:00","start_date_details":{"year":"2021","month":"03","day":"31","hour":"09","minutes":"00","seconds":"00"},"end_date":"2021-03-31 09:00:00","end_date_details":{"year":"2021","month":"03","day":"31","hour":"09","minutes":"00","seconds":"00"},"utc_start_date":"2021-03-31 07:00:00","utc_start_date_details":{"year":"2021","month":"03","day":"31","hour":"07","minutes":"00","seconds":"00"},"utc_end_date":"2021-03-31 07:00:00","utc_end_date_details":{"year":"2021","month":"03","day":"31","hour":"07","minutes":"00","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CEST","cost":"","cost_details":{"currency_symbol":"","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"Thesis","slug":"theses-en","term_group":0,"term_taxonomy_id":187,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":254,"filter":"raw","id":187,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/187","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"<span>Thesis defense – <\/span>Cynthia Alkhoury Abboud","description":"<p>Peptidergic control of pain: modulation of descending pathways by the relaxin systems<\/p>\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-cynthia-alkhoury-abboud\/","startDate":"2021-03-31T09:00:00+02:00","endDate":"2021-03-31T09:00:00+02:00","performer":"Organization"}}