{"id":115713,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=115713","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=115713"],"author":"108","status":"publish","date":"2020-02-03 15:41:27","date_utc":"2020-02-03 14:41:27","modified":"2020-02-04 10:36:01","modified_utc":"2020-02-04 09:36:01","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminaire-impromptu-joshua-goldberg\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/115713","title":"Impromptu seminar &#8211; Joshua Goldberg","description":"<p>Venue: Centre Broca nouvelle-Aquitaine<\/p>\n<hr \/>\n<p><em><strong>A neuroprotective response to a-synuclein causes dysautonomia in models of prodromal Parkinson\u2019s disease<\/strong><\/em><\/p>\n<p><strong><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2020\/02\/goldberg-joshua-.jpg\" rel=\"lightbox[-1]\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-115744 alignleft\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2020\/02\/goldberg-joshua-.jpg\" alt=\"\" width=\"170\" height=\"170\" srcset=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2020\/02\/goldberg-joshua-.jpg 200w, https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2020\/02\/goldberg-joshua--80x80.jpg 80w\" sizes=\"auto, (max-width: 170px) 100vw, 170px\" \/><\/a>Joshua A. Goldberg,<br \/>\n<\/strong>Department of Medical Neurobiology, Institute of Medical Research Israel \u2013 Canada,<br \/>\nThe Faculty of Medicine, The Hebrew University of Jerusalem, 9112102 Jerusalem, Israel<br \/>\n<a href=\"mailto:joshua.goldberg2@mail.huji.ac.il\">joshua.goldberg2@mail.huji.ac.il<\/a><\/p>\n<p><strong><a href=\"http:\/\/goldberglab.net\/\">http:\/\/goldberglab.net\/<\/a><\/strong><\/p>\n<h1>Abstract<\/h1>\n<p>No disease-modifying therapy is currently available for Parkinson\u2019s disease (PD), the second most common neurodegenerative disease. The long non-motor prodromal phase of PD is a window of opportunity for early detection and intervention. By developing a mutant a-synuclein selective overexpression mouse model of prodromal PD, we identified a cell-autonomous shrinkage of dorsal motor nucleus of the vagus (DMV) cholinergic neurons. In response to the shrinkage, DMV neurons successfully downregulate the surface expression of Cav channels to normalize calcium current density, but fail to downregulate Kv4 channel density. This functional remodeling of DMV neurons has two clinically-relevant implications: first, the elevated Kv4 current density impairs pacemaker function <em>in vitro<\/em> and <em>in vivo<\/em>, which in turn reduces gastrointestinal motility and alters cardiac function; second, the downregulation of Cav currents reduces basal oxidant stress in these neurons in transgenic mice that overexpress a-synuclein, which may explain why they are more resilient than other neurons vulnerable to a-synucleinopathy in PD. These findings can facilitate the rational design of physiological biomarkers to identify people at risk for PD.<\/p>\n<hr \/>\n<p>Invited by <strong><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/staff\/francois-georges\/\">Fran\u00e7ois Georges<\/a><\/strong> &#8211; IMN<\/p>","excerpt":"<p>A neuroprotective response to a-synuclein causes dysautonomia in models of prodromal Parkinson\u2019s disease<\/p>","slug":"seminaire-impromptu-joshua-goldberg","image":false,"all_day":false,"start_date":"2020-02-10 11:30:00","start_date_details":{"year":"2020","month":"02","day":"10","hour":"11","minutes":"30","seconds":"00"},"end_date":"2020-02-10 12:30:00","end_date_details":{"year":"2020","month":"02","day":"10","hour":"12","minutes":"30","seconds":"00"},"utc_start_date":"2020-02-10 10:30:00","utc_start_date_details":{"year":"2020","month":"02","day":"10","hour":"10","minutes":"30","seconds":"00"},"utc_end_date":"2020-02-10 11:30:00","utc_end_date_details":{"year":"2020","month":"02","day":"10","hour":"11","minutes":"30","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CET","cost":"","cost_details":{"currency_symbol":"","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"For scientists","slug":"for-scientists","term_group":0,"term_taxonomy_id":301,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":771,"filter":"raw","id":301,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/301","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}},{"name":"home-event","slug":"home-event","term_group":0,"term_taxonomy_id":285,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":812,"filter":"raw","id":285,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/285","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}},{"name":"Impromptu seminar","slug":"impromptu-seminar","term_group":0,"term_taxonomy_id":212,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":194,"filter":"raw","id":212,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/212","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Impromptu seminar &#8211; Joshua Goldberg","description":"&lt;p&gt;A neuroprotective response to a-synuclein causes dysautonomia in models of prodromal Parkinson\u2019s disease&lt;\/p&gt;\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminaire-impromptu-joshua-goldberg\/","startDate":"2020-02-10T11:30:00+01:00","endDate":"2020-02-10T12:30:00+01:00","performer":"Organization"}}