{"id":101925,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=101925","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=101925"],"author":"108","status":"publish","date":"2018-06-07 17:26:31","date_utc":"2018-06-07 15:26:31","modified":"2019-10-30 16:48:13","modified_utc":"2019-10-30 15:48:13","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminar-yasunori-hayashi\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/101925","title":"Seminar &#8211; Yasunori Hayashi","description":"<p class=\"content-author\"><strong><a href=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2018\/06\/Hayashi280p.jpg\" rel=\"lightbox[-1]\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-56744\" src=\"https:\/\/www.bordeaux-neurocampus.fr\/wp-content\/uploads\/2018\/06\/Hayashi280p.jpg\" alt=\"\" width=\"210\" height=\"144\" \/><\/a>Yasunori Hayashi<\/strong><br \/>\nPhD, Department of Pharmacology<br \/>\nKyoto University Graduate School of Medicine<\/p>\n<p class=\"content-author\"><strong>Invitant : Daniel Choquet<\/strong><br \/>\nDirecteur de L&#8217;IINS<\/p>\n<h2>Abstract :<\/h2>\n<p><strong>Long-term synaptic plasticity requires a mechanism that converts short Ca2+ pulses into persistent <\/strong>biochemical signaling to support the changes in the function and structure of synapses over long period of time. Here, we present a positive feedback loop, formed by a &#8220;reciprocally activating kinase-effector complex&#8221; (RAKEC) in dendritic spines, enabling the persistence and confinement of the molecular memory. We found that stimulation of a single spine causes the rapid formation of a RAKEC consists of a kinase CaMKII and its substrate a RacGEF TIAM1, which can stably promote actin-polymerization through Rac1, thereby maintaining the structure of the spine over a long period of time during LTP. This is achieved by a pseudo-autoinhibitory domain found within TIAM1, homologous to the autoinhibitory domain of CaMKII. RAKEC can store biochemical information in small subcellular compartments, thus potentially serving as a general mechanism for the production of prolonged and compartmentalized signaling.<\/p>","excerpt":"<p>The mechanism converting a transient Ca2+-signaling into persistent biochemical signaling during LTP. <\/p>","slug":"seminar-yasunori-hayashi","image":false,"all_day":false,"start_date":"2018-07-13 11:30:00","start_date_details":{"year":"2018","month":"07","day":"13","hour":"11","minutes":"30","seconds":"00"},"end_date":"2018-07-13 11:30:00","end_date_details":{"year":"2018","month":"07","day":"13","hour":"11","minutes":"30","seconds":"00"},"utc_start_date":"2018-07-13 09:30:00","utc_start_date_details":{"year":"2018","month":"07","day":"13","hour":"09","minutes":"30","seconds":"00"},"utc_end_date":"2018-07-12 22:00:00","utc_end_date_details":{"year":"2018","month":"07","day":"12","hour":"22","minutes":"00","seconds":"00"},"timezone":"Europe\/Paris","timezone_abbr":"CEST","cost":"","cost_details":{"currency_symbol":"","currency_position":"","values":[]},"website":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminar-yasunori-hayashi\/","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[{"name":"home-event","slug":"home-event","term_group":0,"term_taxonomy_id":285,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":810,"filter":"raw","id":285,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/285","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}},{"name":"Seminars","slug":"seminars","term_group":0,"term_taxonomy_id":186,"taxonomy":"tribe_events_cat","description":"","parent":0,"count":125,"filter":"raw","id":186,"urls":{"self":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories\/186","collection":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/categories"}}],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Seminar &#8211; Yasunori Hayashi","description":"&lt;p&gt;The mechanism converting a transient Ca2+-signaling into persistent biochemical signaling during LTP. &lt;\/p&gt;\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/seminar-yasunori-hayashi\/","startDate":"2018-07-13T11:30:00+02:00","endDate":"2018-07-13T11:30:00+02:00","performer":"Organization"}}