{"id":101887,"global_id":"www.bordeaux-neurocampus.fr\/en\/?id=101887","global_id_lineage":["www.bordeaux-neurocampus.fr\/en\/?id=101887"],"author":"108","status":"publish","date":"2018-12-04 18:47:20","date_utc":"2018-12-04 17:47:20","modified":"2020-01-21 11:24:19","modified_utc":"2020-01-21 10:24:19","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-thomas-kerloch\/","rest_url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/wp-json\/tribe\/events\/v1\/events\/101887","title":"Thesis defense – Thomas Kerloch","description":"

[vc_row][vc_column][vc_column_text]Etude du d\u00e9veloppement des neurones granulaires du gyrus dent\u00e9: morphog\u00e9n\u00e8se\u00a0et r\u00e9gulation par Rnd2<\/strong><\/p>\n

Le 26 novembre 2018, \u00e0 14h.<\/strong><\/p>\n

Directeur de th\u00e8se: Emilie Pacary<\/strong>\u00a0du Neurocentre Magendie, \u00e9quipe Nora Abrous teamleader: “Neurog\u00e9n\u00e8se et physiopathologie”<\/p>\n

\u00a0In most areas of the brain, neurons are born during embryogenesis. In contrast, the majority of granule neurons in the dentate gyrus (DG) of the hippocampus are born postnatally and their generation continues throughout adulthood.<\/strong>\u00a0This finding that new neurons are generated in the adult mammalian brain has opened novel avenues for brain repair and has initiated, in the last 20 years, tremendous efforts to characterize how new neurons differentiate and integrate into adult neural circuitries.
\nHowever, further studies are needed to better understand the mechanisms and signaling cascades involved in this process. In this context, we focused on Rnd2, a Rho GTPase particularly enriched in the adult neurogenic DG and described as a key player in the regulation of embryonic cortical neurogenesis.<\/p>\n

We found, in vivo, that the deletion of Rnd2 specifically in adult-born hippocampal neurons decreases the survival of these cells, and in the surviving ones, leads to soma hypertrophy, increases dendritic arborization and induces mispositionning. Importantly, this deletion also increases anxiety-like behavior in mice, thus identifying Rnd2 as a critical regulator of adult newborn neuron development and function. In addition, our data show that Rnd2 does not play the same functions in granule neurons born at P0, highlighting a differential regulation of developmental and adult neurogenesis in the DG. In the same vein, we also demonstrate that perinatally-born granule neurons, especially the embryonic ones, are morphologically distinct compared with later-born neurons. Altogether, this PhD work provides new insights into the development of the different populations of granule neurons in the DG, further emphasizing the peculiarity of this brain structure.<\/p>\n

 <\/p>\n

Publications
\n<\/strong><\/p>\n

Roberta Azzarelli, Thomas Kerloch, Emilie Pacary.\u00a0Regulation of cerebral\u00a0<\/strong><\/em>
\ncortex development by Rho GTPases: insights from in vivo studies.<\/strong>\u00a0Front\u00a0<\/em>
\nCell Neurosci. (2015) 7;8:445 doi: 10.3389\/fncel.2014.00445 (revue).<\/em><\/p>\n

Thomas Kerloch, Sol\u00e8ne Clavreul, Adeline Goron, Djoher Nora Abrous,\u00a0<\/em>
\nEmilie Pacary.\u00a0Dentate granule neurons generated during perinatal life\u00a0<\/strong><\/em>
\ndisplay distinct morphological features compared with later-born neurons\u00a0<\/em><\/strong>
\nin the mouse hippocampus.<\/strong>\u00a0Cereb. Cortex. (2018) doi:\u00a0<\/em>
\n10.1093\/cercor\/bhy224.<\/em><\/p>\n

Thomas Kerloch, Fanny Farrugia, Marl\u00e8ne Ma\u00eetre, Muriel Koehl, Myl\u00e8ne\u00a0<\/em>
\nBlanchard, H\u00e9l\u00e8ne Doat, Thierry Leste-Lasserre, Julian Ik-Tsen Heng,\u00a0<\/em>
\nAdeline Goron, Delphine Gonzales, Djoher Nora Abrous, Emilie Pacary.\u00a0<\/em>
\nRnd2 is essential for granule neuron development in the adult\u00a0<\/em><\/strong>
\nhippocampus and serves a critical role in anxiety-like behavior.<\/strong>\u00a0En\u00a0<\/em>
\npr\u00e9paration.<\/em><\/p>\n

JURY<\/h3>\n
\n

Dr. Violaine MOREAU<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Bordeaux\u00a0<\/em>
\nPr\u00e9sidente
\nDr. Olivier RAINETEAU<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Lyon\u00a0<\/em>
\nRapporteur
\nPr. Nicolas TONI<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Lausanne\u00a0<\/em>
\nRapporteur
\nDr. Fran\u00e7ois GUILLEMOT<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Londres\u00a0<\/em>
\nExaminateur
\nDr. Emilie PACARY<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Bordeaux\u00a0<\/em>
\nDirectrice de th\u00e8se
\nDr. Djoher Nora ABROUS<\/strong>\u00a0<\/em>
\nUniversit\u00e9 de Bordeaux\u00a0<\/em>
\nInvit\u00e9e<\/em><\/p>\n<\/div>\n

[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","excerpt":"

Etude du d\u00e9veloppement des neurones granulaires du gyrus dent\u00e9: morphog\u00e9n\u00e8se et r\u00e9gulation par Rnd2<\/p>","slug":"thesis-defense-thomas-kerloch","image":false,"all_day":true,"start_date":"2018-11-26 00:00:00","start_date_details":{"year":"2018","month":"11","day":"26","hour":"00","minutes":"00","seconds":"00"},"end_date":"2018-11-26 23:59:59","end_date_details":{"year":"2018","month":"11","day":"26","hour":"23","minutes":"59","seconds":"59"},"utc_start_date":"2018-11-25 23:00:00","utc_start_date_details":{"year":"2018","month":"11","day":"25","hour":"23","minutes":"00","seconds":"00"},"utc_end_date":"2018-11-26 22:59:59","utc_end_date_details":{"year":"2018","month":"11","day":"26","hour":"22","minutes":"59","seconds":"59"},"timezone":"Europe\/Paris","timezone_abbr":"CET","cost":"","cost_details":{"currency_symbol":"","currency_position":"prefix","values":[]},"website":"","show_map":false,"show_map_link":false,"hide_from_listings":false,"sticky":false,"featured":false,"categories":[],"tags":[],"venue":[],"organizer":[],"json_ld":{"@context":"http:\/\/schema.org","@type":"Event","name":"Thesis defense – Thomas Kerloch","description":"<p>Etude du d\u00e9veloppement des neurones granulaires du gyrus dent\u00e9: morphog\u00e9n\u00e8se et r\u00e9gulation par Rnd2<\/p>\\n","url":"https:\/\/www.bordeaux-neurocampus.fr\/en\/event\/thesis-defense-thomas-kerloch\/","startDate":"2018-11-26T00:00:00+01:00","endDate":"2018-11-26T23:59:59+01:00","performer":"Organization"}}