1.0Bordeaux Neurocampushttps://www.bordeaux-neurocampus.fr/en/Oliet Stéphanehttps://www.bordeaux-neurocampus.fr/en/author/stephane-olietinserm-fr/rich600338<blockquote class="wp-embedded-content" data-secret="J1iBBF8KyY"><a href="https://www.bordeaux-neurocampus.fr/en/team/glia-neuron-interactions/">Glia-neuron interactions</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.bordeaux-neurocampus.fr/en/team/glia-neuron-interactions/embed/#?secret=J1iBBF8KyY" width="600" height="338" title="“Glia-neuron interactions” — Bordeaux Neurocampus" data-secret="J1iBBF8KyY" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript"> /* <![CDATA[ */ /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); //# sourceURL=https://cdn-neurocampus.onlc.eu/wp-includes/js/wp-embed.min.js /* ]]> */ </script> Our aim is to understand the biological bases of glia-neurons interactions in healthy and diseased nervous system (chronic pain, Alzheimer disease and multiple sclerosis). We showed the contribution of astrocyte to synaptic functions by showing the role of D-serine, a gliotransmitter released by astrocytes, in gating synaptic NMDA receptors and their dependent long-term plasticity. We are now also interested in analyzing fine morphological plasticity of astroglial cells as well as monitoring membrane trafficking of key proteins at the surface of astrocytes. Innovative techniques | In vitro electrophysiology, morphological analysis, MRI, chronic pain rat model