1.0Bordeaux Neurocampushttps://www.bordeaux-neurocampus.fr/en/Frick Andreashttps://www.bordeaux-neurocampus.fr/en/author/andreas-frickinserm-fr/Cortical plasticity - Bordeaux Neurocampusrich600338<blockquote class="wp-embedded-content" data-secret="DU4CBxGp7J"><a href="https://www.bordeaux-neurocampus.fr/en/team/cortical-plasticity/">Cortical plasticity</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.bordeaux-neurocampus.fr/en/team/cortical-plasticity/embed/#?secret=DU4CBxGp7J" width="600" height="338" title="“Cortical plasticity” — Bordeaux Neurocampus" data-secret="DU4CBxGp7J" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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Our research topic is focused on the structure, function and dynamic regulation of cortical circuits in various conditions such as learning, development and disease. We investigate ion channel function in the different neuronal compartment to predict/analyse the coding properties of cortical neurons alone or in cell assembly. Using genetic models, we revealed the implication of ion channel dysfunctions in the hypersensitivity in response to sensory stimuli associated to neocortical hyperexcitability, features of fragile X syndrome and autism. We also study the anatomical connectivity of neocortical circuits and showed that its alterations named as a "connectopathy," cause functional defects that may…