1.0Bordeaux Neurocampushttps://www.bordeaux-neurocampus.fr/en/Giannone Gregoryhttps://www.bordeaux-neurocampus.fr/en/author/gregory-giannoneu-bordeaux-fr/Actin dynamics in cell migration. - Bordeaux Neurocampusrich600338<blockquote class="wp-embedded-content" data-secret="NWjdgYUaEl"><a href="https://www.bordeaux-neurocampus.fr/en/article/actin-dynamics-in-cell-migration/">Actin dynamics in cell migration.</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.bordeaux-neurocampus.fr/en/article/actin-dynamics-in-cell-migration/embed/#?secret=NWjdgYUaEl" width="600" height="338" title="“Actin dynamics in cell migration.” — Bordeaux Neurocampus" data-secret="NWjdgYUaEl" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript">
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Abstract Cell migration is an essential process, both in unicellular organisms such as amoeba and as individual or collective motility in highly developed multicellular organisms like mammals. It is controlled by a variety of activities combining protrusive and contractile forces, normally generated by actin filaments. Here, we summarize actin filament assembly and turnover processes, and how respective biochemical activities translate into different protrusion types engaged in migration. These actin-based plasma membrane protrusions include actin-related protein 2/3 complex-dependent structures such as lamellipodia and membrane ruffles, filopodia as well as plasma membrane blebs. We also address observed antagonisms between these protrusion types,…