Marion Bosc

Doubt-related checking in non-human primate: a behavioral and electrophysiological study

Defended on December 16, 2016

Team : “Physiologie et physiopathologie des fonctions exécutives” / Thomas Boraud and Pierre Burbaud IMN/

 Checking behavior is essential to maximizing gain and/or minimizing loss in our daily lives and relies on a normal action monitoring process. Although several studies have explored the neurobiological basis of doubt and uncertainty, both the physiology and physiopathology of checking, its most manifest behavioral consequence, remain poorly understood. This PhD project aims at characterizing physiological doubt and checking behavior in non-human primates. To do so, we trained two rhesus monkeys at a newly designed Check-or-Go task that allows the animal to multiple-check and change the availability of a reward before taking the final decision leading to that reward. During the task, we recorded frontal EEG activity and single neuronal activity in the rostral part of the ACC (CMAr), and the pre-supplementary motor area (pre-SMA), and quantified salivary cortisol in order to correlate this biological marker of anxiety with checking behavior. Our results show that, as humans, monkeys have the metacognitive ability to express voluntary checking behavior that depends on uncertainty monitoring, relates to anxiety and involves brain frontal areas..

Bosc M., Bioulac B., Langbour N., Nguyen TH., Goillandeau M., Dehay B., Burbaud P & Michelet T. (2016). Doubt and checking behavior in monkeys. Scientific Reports (under revision). 


  • Dr. BORAUD Thomas

    DR  –
    Université de Bordeaux  – Président
  • Dr. JAAFARI Nematollah
    Maître de conférences  – Université de Poitiers  – Rapporteur
  • Dr. PROCYK Emmanuel
    Directeur de recherche  – Université de Lyon – Rapporteur
  • Pr. BIOULAC Bernard
    Professeur des Universités  – Université de Bordeaux – Membre invité

PhD supervisor

Dr Thomas Michelet
MCU dans l’équipe : Physiology and pathophysiology of executive functions (Pierre Burbaud, Thomas Boraud) IMN

Last update: 4 April 2018