PhD: Matthias Haberl

Studying Neuronal Connectivity in the Mouse Brain in Normal Condition and Fragile X Syndrome

Defended on October 16, 2014

The goal of this work was the investigation of the anatomical and functional connectivity of neuronal networks and the development of novel tools for this purpose. Since the latter aspect is a major focus of current neuroscience, we first sought a novel viral tracer enabling sparse neuronal reconstruction and neuron classification. We then applied this and other techniques to probe neuronal connectivity defects in Fragile X Syndrome..


– Revealing the secrets of neuronal circuits with recombinant rabies virus technology. Melanie Ginger*, Matthias Haberl*, Karl-Klaus Conzelmann, Martin K. Schwarz and Andreas Frick. *Equal contributions. Frontiers in Neural Circuits, Published online January 24, 2013

– An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology. Matthias Georg Haberl*, Silvia Viana da Silva*, Jason M. Guest, Melanie Ginger, Alexander Ghanem, Christophe Mulle, Marcel Oberlaender, Karl-Klaus Conzelmann and Andreas Frick. *Equal contributions. Brain Structure and Function, Published online April 11, 2014

– Use of Rhabdoviruses to Study Neural Circuitry. Melanie Ginger*, Guillaume Bony*, Matthias Haberl and Andreas Frick. *Equal contributions. Bookchapter in Biology and Pathogenesis of Rhabdo- and Filoviruses

PhD committee

  • Dr. Ingrid Bureau
    (INMED Marseille)
  • Prof. Dr. Arend Heerschap
    (UMC Radboud)
  • Prof. Dr. Jean-Pascal Pfister
    (INI Zurich)
  • Andreas Frick
    Directeur de thèse
  • Kevan Martin

    (Institute for Neuroinformatics, UZH/ETH Zurich)

Thesis supervisor

Andreas Frick, PhD
Team”Circuit and dendritic mechanisms underlying cortical plasticity”
Neurocentre Magendie
INSERM U862, University Bordeaux 2

Last update: 16 October 2014