HDR: Philippe Ciofi

Immunohistochemical contributions to the knowledge of the organization and plasticity of neuroendocrine systems.

Le 5 avril 2004

The discovery of the neuropeptides, these messengers with modulatory function, has led to the establishment by immunohistochemical techniques of a chemical neuroanatomy of the brain. This given opportunity of charaterizing neuronal systems through their pharmacological phenotype allowed an access to both their organization and metabolism under physiological or experimental conditions.
Thereby, hypothalamic peptidergic circuits controlling reproductive physiology and behavior appeared endowed of striking functional plasticity.For example, during the period of sexual differentiation of the developping brain. Or from puberty onward, in response to fluctuating levels of circulating gonadosteroids.
My works are aimed at discriminating the role of hypothalamic networks in the control of anterior pituitary functions by studying, their responses to gonadosteroids or reproductive status, their intrinsic organization and their anatomical place.


  • André Calas, Professeur à l’Université Pierre et Marie Curie-Paris VI, Rapporteur
  • Jacques Epelbaum, Directeur de Recherche à l’INSERM, Paris, Examinateur
  • Dominique Poulain, Directeur de Recherche à l’INSERM, Bordeaux, Examinateur
  • Pierre-Yves Risold, Chargé de Recherche à l’INSERM, Besançon, Rapporteur
  • Gérard Tramu, Professeur à l’Université de Bordeaux I, Rapporteur
Last update: 5 April 2004