Tobacco smoking and brain atrophy in the elderly subject.
Defended on December 17 2014
Summary: Increase in life expectancy seen during the XXth century, followed by an increase in the proportion of elderly, has placed the study of brain aging and of its accompanying diseases in the spotlight. This thesis aimed at quantifying of the impact of tobacco consumption on brain morphological aging in a large cohort of healthy elderly subjects from the Three Cities Study. We focused on the evaluation and comparison of its impact as compared to other factors known to influence brain aging, in longitudinal and cross-sectional studies. We show that tobacco smoking has mainly global effects, albeit with somme differences depending on brain tissue type, more important than that of other cardiovascular risk factors included in this study and as important as the effect of age. Also, we have found that this effect stops whe subjects quit smoking, showing that prevention among the elderly population might be of major interest. Moreover, analysis have been conducted in men and women separately, allowing us to find differential effects of tobacco consumption on the brain morphological aging in the two sexes. These original findings, that for the most part have never been repported in the literature, need to be replicated in another cohort.
Duriez Q, Crivello F, Mazoyer B (2014). “Sex-related and tissue-specific effects of tobacco smoking on brain atrophy: assessment in a large longitudinal cohort of healthy elderly.” Front Aging Neurosci 6:299. doi: 10.3389/fnagi.2014.00299
- Hugues Chabriat
Rapporteur (Université Paris Diderot – ParisVII)
- Alexandre Krainik
Rapporteur (Université Joseph Fournier Grenoble)
- Christophe Tzourio
Examinateur (Université de Bordeaux)
- Bernard Mazoyer
Directeur de thèse (GIN / Univ Bordeaux)
Directeur du Groupe d’Imagerie Neurofonctionnelle
UMR5296, CNRS, CEA, Université de Bordeaux