#

Study Engineer in a research laboratory

Work Environment:
The Neurodegen sub-project of the GPR Brain_2030 is recruiting a Biology Engineer (https://www.bordeaux-neurocampus.fr/brain_2030-labellise-gpr/). The project focuses on the study of common and divergent mechanisms underlying defective cell-to-cell communication in three neurodegenerative diseases (Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis). The candidate will work on the implementation and execution of the project. The University of Bordeaux, in the environment of the Bordeaux Neurocampus, constitutes an international and stimulating environment, recognized worldwide.

Workplace:
Interdisciplinary Institute of NeuroScience, IINS CNRS UMR5297, Bordeaux

Contact:



Missions:
The main missions of the engineer will be to carry out experiments within the framework of the project in collaboration with the coordinators, the research engineer and the teams participating in the project. He/she will participate in the analysis of the central nervous system of different experimental models of the 3 pathologies; to condition them for specific and different analyses; to conduct, within the framework of an experimental program, all or part of the biology techniques (cell biology and biochemistry, electrophysiology…) to characterize animal models and cellular models to be prepared in close collaboration with the teams.

Activities:

▪ Set up and follow up the different stages of the project with the teams and platforms;

▪ Perform animal (rodent) sampling following pre-established protocols;

▪ Prepare samples by different biology techniques (subcellular fractionation, synaptosome isolation, FACS);

▪ Perform proteomics analysis in coordination w the Proteome facility (Label-free LC-MS/MS analysis).

▪ Validate proteomic targets using an array of cellular and molecular techniques (immunostainings, immunoblot, genome editing).

▪ Administering viral vectors in rodents.

▪ Participate in inventory and order management within the planned budget;

▪ Collect and format information necessary for the proper conduct of experimentation and/or required by legislation: laboratory notebook, records;

▪ Record and format results according to laboratory standards;

▪ Apply regulations related to animal experimentation activities.

Profile sought:

▪ We are seeking a candidate with a background in neuroscience and/or biochemistry, and/or proteomics. Candidates with other specializations and scientific curiosity beyond their current research are encouraged to apply. The ideal candidate is highly motivated and has experience with preclinical experiments. The Study Engineer will participate in challenging, multidisciplinary projects and contribute to the research outcomes of the various teams.

▪ Education, degree required: Master’s to PhD.

▪ Desired field of training: Cell Biology, Biochemistry, Biotechnology, Neuroscience;

▪ Possible knowledge of the Bordeaux Neurocampus environment. 

Skills

Knowledge

▪ Knowledge of Biology (biochemistry, cell biology).
▪ Practice of animal experimentation and animal surgery techniques
▪ Knowledge of the risks specific to laboratories and the rules of Health and Safety;
▪ English language level B1.

Know-How

▪ Organization and analysis of experimental data;
▪ Maintenance of a laboratory notebook;
▪ Communication of results to research team collaborators.

Savoir-être

▪ Organization;
▪ Thoroughness;
▪ Critical thinking skills;
▪ Interpersonal skills, communication and teamwork skills.

Restriction or constraints related to the position:
Respect the rules of Hygiene and Safety related to the activity in a laboratory; Work in a confined environment; Possible shifts; Not owning domestic rodents.

Taking over:
The second half of 2022

Contract Duration:
The Study Engineer position is for 3 years with a start date of September 2022 (1-year renewable fixed term). The position is advertised until filled. After a screening process, we will conduct zoom interviews with potential candidates. Please send your application to as a single pdf including a cover letter, a CV, a list of publications and the names of 2-3 references.

02/06/22