Post-doctoral position in synapse biology and synucleinopathy
We are seeking to recruit as soon as possible a post-doctoral fellow expert in Molecular and cellular neurobiology and/or physiopathology of neurodegenerative diseases to study new pathways involved in synucleinopathies.
The project aims at studying the role of eEF1A1 and other markers in the early phase of synucleinopathy in mouse models. Building on our recent work using synapse purification and molecular dissection (Hafner, Science, 2019 ; Biesemann, EMBOJ, 2014), we identified early markers of synucleinopathy (Blumenstock, Acta Neuropathol, 2019). In the current project, you will develop molecular and cellular approaches in-vivo to refine our understanding of the mechanisms leading to the pathology.
The position in Bordeaux is funded by an ANR/DZNE CoEN grant to Etienne Herzog (IINS, Bordeaux) and Jochen Herms (DZNE, Munich) for two years. We are seeking highly motivated individuals with a proven track record of success, if possible immediately after their PhD, and in any case no more than four years after their PhD. The project will be conducted in the stimulating and highly interdisciplinary and international environment of IINS and Bordeaux Neurocampus (Bordeaux, France).
Blumenstock S, et al., (2019) Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy. Acta Neuropathol (Berl) August 26
Biesemann C, et al., (2014) Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting. EMBO J 33:157–170.
Hafner A-S, et al., (2019) Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments. Science 364:eaau3644.