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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20260329T010000
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DTSTART;TZID=Europe/Paris:20260703T130000
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SUMMARY:Thesis defense - Elba Molpeceres
DESCRIPTION:Venue : Centre Broca \n \n\nElba Molpeceres\nTeam Monoamines\, Parkinson and pain (Benazzouz / Fossat)\nIMN \nThesis directed by : Abdelhamid Benazzouz \nTitle\nCharacterization of the subthalamo-cortical pathway and its involvement in the pathophysiology of Parkinson’s disease \nAbstract\nThis thesis investigated the role of the STN in pain symptoms of Parkinson’s disease and provided an anatomo-functional characterization of the direct STN-M1 pathway under normal and parkinsonian conditions using chemogenetic\, optogenetic\, behavioral and electrophysiological approaches in Vglut2-cre mice. Our results demonstrated that selective inhibition of STN glutamatergic neurons improves motor and nociceptive deficits induced by 6-OHDA dopaminergic lesion. Anatomical analyses revealed direct STN projections to motor and somatosensory cortices in mice\, with preferential connectivity toward PV+ interneurons of the M1 cortex. Optogenetic inhibition of the STN-M1 pathway attenuated motor and pain-related abnormalities and restored altered nociceptive cortical responses in parkinsonian conditions. These findings identify the STN- M1 pathway as a critical contributor to Parkinson’s disease pathophysiology and highlight its potential therapeutic relevance. \nKey words\nParkinson’s Disease\, Subthalamic nucleus\, Motor symptoms\, Pain \nJury\n\nM. Daniel VOISIN Professeur\, Neurocentre Magendie\, Bordeaux – Président\nMme Veronique COIZET Directrice de recherche\, Institut des Neurosciences de Grenoble\, La Tronche – Rapporteure\nM. Yasin TEMEL Professeur\, Maastricht University\, Maastricht – Rapporteur\nMme Sandrine BERTRAND Directrice de recherche\, INCIA\, Bordeaux – Examinatrice \n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-elba-molpeceres/
CATEGORIES:IMN,Thesis
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