BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Bordeaux Neurocampus - ECPv4.9.10//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20250330T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20251026T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250228T140000
DTEND;TZID=Europe/Paris:20250228T140000
DTSTAMP:20260512T061452
CREATED:20240924T140621Z
LAST-MODIFIED:20241127T103359Z
UID:175735-1740751200-1740751200@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Maëlle Ollivier
DESCRIPTION:Venue: Centre Broca \nDefense in french \n\nMaëlle Ollivier\nINCIA\nThesis supervisor: Sandrine Bertrand \nTitle\nRole of sympathetic autonomic nervous system in amyotrophic lateral sclerosis  \nAbstract\nAmyotrophic lateral sclerosis (ALS) was initially defined by Jean-Martin Charcot in 1869 as a disease exclusively affecting motor neurons. However\, it is now recognized as a multisystem neurodegenerative disease\, characterized by clinical\, genetic\, and neuropathological heterogeneity. Despite increasing advances in understanding Charcot’s disease\, around forty randomized clinical trials have not demonstrated significant therapeutic efficacy. This lack of success may be attributed to several potential factors\, including the approach of treating ALS as a single entity without considering the different underlying causes and mechanisms involved. Although various non-motor symptoms related to autonomic nervous system dysfunctions have been described\, few research projects have investigated the involvement of these alterations in the disease’s development.Therefore\, this thesis focuses on the role of the sympathetic autonomic nervous system in ALS\, using an animal model carrying the SOD1*G93A mutation. Our study primarily focuses on a neuronal population located near motor neurons in the spinal cord\, known as sympathetic preganglionic neurons. These neurons\, considered the final relay of central control over sympathetic vasomotor flow to various organs of the body\, are responsible for autonomous regulation and control\, particularly of cardiac function. By combining genetic\, biochemical\, anatomical techniques with telemetric and behavioral approaches\, we will study the function of preganglionic neurons and cardiovascular control during the development of ALS. \nKey words : amyotrophic lateral sclerosis\, sympathetic autonomic nervous system\, cardiovascular control \nJury\nMme BERTRAND Sandrine\, Directrice de recherche\, INCIA – CNRS UMR 5287\, Directrice de these\nM. ZYTNICKI Daniel\, Directeur de recherche émérite\, SPPIN – CNRS UMR 8003\, Rapporteur\nMme HILAIRE Cécile\, Maîtresse de conférences\, INM – Inserm\, Rapporteure\nMme CHEVALLIER Stephanie\, Maîtresse de conférences\, NEUROCENTRE MAGENDIE – U1215\, Examinatrice\nM. LANDRY Marc\, Professeur des universités\, Institut des Maladies Neurodégénératives – CNRS UMR 5293\, Examinateur\nMme PERRIN Florence\, Professeure des universités\, INM – INSERM U1051\, Examinatric \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-maelle-ollivier/
CATEGORIES:Thesis
END:VEVENT
END:VCALENDAR