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X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART;TZID=Europe/Paris:20210628T140000
DTEND;TZID=Europe/Paris:20210628T140000
DTSTAMP:20260605T074436
CREATED:20210329T130711Z
LAST-MODIFIED:20210611T194506Z
UID:134329-1624888800-1624888800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Camille Quilgars
DESCRIPTION:\n	\n		\n			Auditorium of the CGFB \n\nDefense in french \nTitle : Impact of motor training on motor spinal network development \nAbstract\nMy doctoral work is centered around two axes: \nAxe 1. Exercise and physical activity are now recognized for their short- or long-term benefits on health and are commonly used in combination with pharmacological treatment to treat several pathologies and to promote functional recovery after trauma. Numerous studies have revealed that dynamic reconfigurations occur in the spinal networks in charge of the locomotor command\, when the motor activity is increased or modified. The majority of these data arise from adult rodents. At birth\, mouse and rat pups cannot walk due to an immature postural control and exhibit an adult like locomotor pattern around the postnatal day 12 (P15). In the present study\, we provide the first investigation of the impact of a swim training performed during the early postnatal development of mice on motor spinal circuits. By combining behavioral\, electrophysiological\, genomic and biochemical approaches\, we show that a transient motor training performed during the two first postnatal days is sufficient to accelerate the maturation of swim pattern in newborn mice\, to reshape the transcriptome of motoneurons (MNs) and to alter the synaptic plasticity expressed at reticulospinal synapses as well as some MN intrinsic membrane properties. Moreover\, we report that long term effects of the training protocol used could be observed as the monoaminergic spinal contents were increased during the second postnatal week following training. Altogether our data reveal that few changes in the level of activity of the spinal networks could lead to dramatic developmental alterations when performed in the early postnatal life of mouse pups. \nAxe 2. Developmentally regulated modulation of lumbar motoneurons by metabotropic glutamate receptors. Metabotropic glutamate receptors (mGluRs) play a major role in the modulation of synaptic transmission and neuronal membrane properties in the central nervous system. In lumbar MNs\, the role of mGluRs is largely ignored. Our data show that extensor and flexor MNs exhibit different mGluR expression that is developmentally regulated during the two first postnatal weeks. We performed a detailed electrophysiological analysis of the effects of mGluRs agonists on MN membrane properties and synaptic plasticity as well as their functional impact in behaving animals. \nKeywords: Activity-dependent development\, Plasticity\, Motoneuron\, Motor training\, Glutamatergic neuromodulation. \n\n		\n	\n\n	\n		\n			Camille Quilgars\nINCIA \nThesis supervisor: Sandrine Bertrand (INCIA) \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-camille-quilgars/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20210628T140000
DTEND;TZID=Europe/Paris:20210628T140000
DTSTAMP:20260605T074436
CREATED:20210604T151216Z
LAST-MODIFIED:20210621T161231Z
UID:135687-1624888800-1624888800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Hisham Forrière
DESCRIPTION:\n	\n		\n			Videoconfence: https://u-bordeaux-fr.zoom.us/j/84148960532 \nDefense in french \n\nTitle\nMicroscopie par localisation de molécules individuelles en profondeur utilisant la technologie sospim et l’optique adaptative.\n(Single Molecule Localization Microscopy in depth using soSPIM and adaptive optics) \nAbstract\nAdvances in scientific knowledge are often correlated with the development of new instrumental techniques. Biology is no exception to the rule. The recent development of super–resolution fluorescence microscopy techniques\, awarded by the Nobel Prize in Chemistry in 2014\, has revolutionized the way biological samples are observed by allowing to overcome the resolution limit dictated by light diffraction (~200nm) and previously considered insurmountable. Among these techniques\, Single Molecule Localization Microscopy (SMLM) allows to image the organization of proteins inside cells with the best spatial resolutions (~10nm) and gives the possibility to follow their dynamics over time. These new capabilities open the way to a better understanding of the cellular machinery\, essential to better fight against its dysfunctions at the origin of many diseases. \nHowever\, the detection of single molecules for super–resolution imaging by SMLM is particularly challenging and requires both high optical sectioning and high signal collection efficiency. As a result\, it is performed using specialized microscopy systems with extremely shallow sample penetration depths. The single–lens light sheet microscopy system developed in our team\, named soSPIM\, allows to overcome this limitation. By combining a deep optical sectioning with the use of a high numerical aperture objective\, it allows the detection of individual molecules several tens of microns above a coverslip.  \nImaging whole volumes\, such as whole cells\, at these depths\, however\, rises new challenges. In excitation\, light diffraction imposes a significant trade–off between the fineness of sectioning that can be achieved and the field of view. To overcome this\, I sought to implement non–diffractive light sheet illumination to the soSPIM system. In detection\, the performance of SMLM imaging depends directly on the optical quality of the system. Defects\, called optical aberrations\, appear systematically with the imaging depth. To correct these aberrations\, I have implemented an adaptive optics system in the soSPIM microscope to allow precise 3D localization of individual molecules at depth. Finally\, beyond the optical challenges\, the acquisition and reconstruction procedures themselves present many difficulties. I have therefore developed several tools to considerspatial drifts and acquisition automation\, and to reconstruct imaged volumes (~20x20x20 μm3) with nanometric resolutions. These developments have allowed the imaging of whole cells at 30μm depth with resolutions of 5nm radially (x\,y) and 25nm axially (z). This work provides a solid proof of concept of the soSPIM system’s in depthSMLM imaging capability andpaves the way for the observation of new biological structures at previously inaccessible nanometer resolutions. \nKeywords: Adaptive Optics\, Light–Sheet Microscopy\, Single Molecules Localization Microscopy\, Super–Resolution\, Drift Correction\, Non–DiffractiveBeam \nJury\nRémi Galland : Directeur de thèse\nValentin Nägerl : Président\nSandrine Leveque-Fort : Rapportrice\nAlexandra Fragola : Rapportrice \n\n		\n	\n\n	\n		\n			 \nHisham Forrière \nSibarita’s team\nIINS \nThesis supervisor : Rémi Galland \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-hisham-forriere/
CATEGORIES:Thesis
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DTSTART;TZID=Europe/Paris:20210628T140000
DTEND;TZID=Europe/Paris:20210628T140000
DTSTAMP:20260605T074436
CREATED:20210625T081806Z
LAST-MODIFIED:20210625T081806Z
UID:136397-1624888800-1624888800@www.bordeaux-neurocampus.fr
SUMMARY:Soutenance de thèse - Pierrick Laulan
DESCRIPTION:Amphi E (Site Victoire). \nOu via Zoom : https://u-bordeaux-fr.zoom.us/j/82082400152\nID de réunion : 820 8240 0152 \nTitre\nMémoire des mots émotionnels : études inter-tâches des effets de valence et d’arousal \n\nThèse interdisciplinaire effectuée au LabPsy et à l’INCIA\, sous la direction de Stéphanie Mathey et de Gwénaëlle Catheline. \nPublications\nPublications dans des revues à comité de lecture : \n\nLaulan\, P.\, Catheline\, G.\, Mayo\, W.\, Robert\, C.\, & Mathey\, S. (2020). L’effet de positivité lié à l’âge: oublier le négatif et/ou se rappeler du positif? Une étude inter-tâches. Gériatrie et Psychologie Neuropsychiatrie du Vieillissement\, 18(4)\, 437-447.\n\nCommunications : \n\nLaulan\, P.\, Catheline\, G.\, Mayo\, W.\, Robert\, C.\, Mathey\, S. (2020\, novembre). L’effet des caractéristiques émotionnelles des mots sir la reconnaissance visuelle et la mémorisation : une comparaison inter-tâches. Communication affichée présentée lors du colloque « Langage et éMOTions »\, Bordeaux\, France (effectué en dématérialisé).\nLaulan\, P.\, Catheline\, G.\, Mayo\, W.\, Robert\, C.\, Mathey\, S. (2019\, septembre). The positivity effect in aging: forgetting the negative and/or remembering the positive? Communication orale au colloque “Vieillissement : tours\, contours et perspectives”\, Tours\, France.\nLaulan\, P.\, Catheline\, G.\, Mayo\, W.\, Robert\, C.\, Mathey\, S. (2018\, septembre). Memory of low-arousal emotional words in young and older adults. Communication affichée présentée lors du congrès “Aging of Memory Functions: Where are we now ?”\, Bordeaux\, France.\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/soutenance-de-these-pierrick-laulan/
CATEGORIES:Thesis
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