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DTSTART:20190331T010000
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DTSTART:20191027T010000
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DTSTART;TZID=Europe/Paris:20190712T113000
DTEND;TZID=Europe/Paris:20190712T113000
DTSTAMP:20260502T231501
CREATED:20190423T140256Z
LAST-MODIFIED:20191030T154756Z
UID:105963-1562931000-1562931000@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Stefan Hallermann
DESCRIPTION:Venue: Centre Broca Nouvelle Aquitaine \n\n  \nStefan Hallerman\nDr. Stefan Hallermann\nCarl-Ludwig-Institute for Physiology\nUniversity Leipzig – Germany \nhttp://physiologie.medizin.uni-leipzig.de/?de\,id49 \n  \nInvited by Christophe Mulle \nAbstract\nThe presynaptic action potential critically controls synaptic transmission. At experimentally- accessible large nerve terminals\, sodium and potassium channels control the amplitude and duration of action potentials\, respectively. Recently\, potassium channels were found to dynamically regulate action potential amplitude in small nerve terminals and this effect was proposed as a novel mechanism for synaptic plasticity. To investigate this apparent difference between large and small terminals\, we established high-resolution current-clamp recordings from small nerve terminals of cultured neocortical neurons. Using an electrical equivalent circuit and quartz glass pipettes\, we systematically investigated errors related to pipette capacitance and the performance of current-clamp amplifiers. We found rapid action potentials with an amplitude of ~120 mV. Blocking potassium channels prolonged action potentials but did not affect their amplitude. Furthermore\, the spike amplitude was unaffected during short-term and homeostatic plasticity. Thus\, our data indicate large and stable action potential amplitude at small neocortical nerve terminals. \nSelected publications\nHaselmann H\, Mannara F\, Werner C\, Planagumà J\, Miguez-Cabello F\, Schmidl L\, Grünewald B\, Petit-Pedrol M\, Kirmse K\, Classen J\, Demir F\, Klöcker N\, Soto D\, Doose S\, Dalmau J\, Hallermann S\, Geis C (2018) Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction. Neuron 100:91-105 \nRitzau-Jost A\, Jablonski L\, Viotti J\, Lipstein N\, Eilers J\, and Hallermann S. (2018) Apparent calcium dependence of vesicle recruitment. J Physiol 596:4693-707 \nDelvendahl I\, Vyleta NP\, von Gersdorff H\, and Hallermann S. (2016) Fast\, temperature-sensitive and clathrin-independent endocytosis at central synapses. Neuron 90:492-8 \nDelvendahl I\, Jablonski L\, Baade C\, Matveev V\, Neher E\, and Hallermann S. (2015) Reduced endogenous Ca2+ buffering speeds active zone Ca2+ signaling. Proc Natl Acad Sci U S A 112:E3075-84 \nRitzau-Jost A\, Delvendahl I\, Rings A\, Byczkowicz N\, Harada H\, Shigemoto R\, Hirrlinger J\, Eilers J\, and Hallermann S. (2014) Ultrafast action potentials mediate kilohertz signaling at a central synapse. Neuron 84:152-63 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-stefan-hallermann/
CATEGORIES:home-event,Seminars
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