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DTSTART;TZID=Europe/Paris:20261126T140000
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DTSTAMP:20260721T202758
CREATED:20260623T134218Z
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UID:203469-1795701600-1795701600@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Maeva Andriantsoamberomanga
DESCRIPTION:Venue: CARF \n \nThesis defended in english \n\nTeam : NeuroDTx : Neuromodulation et Thérapies Numériques\nIMN \nThesis directed by Amélie Aussel\, Fabien Wagner and Nicolas Rougier \nTitle\nComputational modeling of the hippocampus with detailed neuronal morphology for the interaction of neural oscillations with extracellular electrical stimulation \nAbstract\nSuccessful encoding and retrieval of memory relies on coupling of theta (4-8 Hz) and gamma (30-100Hz) oscillations. Disruption of theta-gamma coupling is observed in pathological states such as Alzheimer’s disease. In recent years\, efforts have been made to slow the progression of the disease\, including the use of Deep Brain Stimulation (DBS) of the memory network. Despite extensive research\, hippocampal electrical stimulation studies yield inconsistent results\, limiting our understanding of its effects on neuronal dynamics and memory. To address this\, I developed a reduced model of hippocampal CA1 region with multicompartment neurons to accurately simulate signal propagation and neuronal recruitment after extracellular stimulation. Three types of neurons (pyramidal\, basket and OLM) were represented with respect to biological ratios taken from the literature. All neurons were modeled following the Hodgkin-Huxley formalism\, and I explicitly modeled trajectories of Schaffer collaterals originating from CA3 and synapsing on pyramidal neurons of CA1. My model exhibits theta-nested gamma oscillations\, balancing computational efficiency with anatomical accuracy to enable tractable and systematic investigation of stimulation parameters and their impact on network dynamics. My simulations demonstrate that bipolar biphasic stimulation induces excitation of the Schaffer collaterals\, subsequently driving excitation in the CA1 network. However\, when the Schaffer collaterals are removed from the model\, the same stimulation protocol induces an inhibitory response within the network. \nKey words\nComputational neuroscience\, Hippocampus\, Memory\, Neural oscillations\, Multicompartment models\, Electrical stimulation \nJury\nMme. Michela CHIAPPALONE\, Professor\, University of Genova – Rapporteure\nM. Gaute EINEVOLL\, Professor\, University of Oslo – Rapporteur\nM. Sabir JACQUIR\, Professeur\, Université Paris-Saclay – Président\nMme. Amélie AUSSEL\, Chargée de Recherche\, Université de Bordeaux – Directrice\nM. Fabien WAGNER\, Chargé de Recherche\, Université de Bordeaux – Co-Directeur\nM. Nicolas ROUGIER\, Directeur de Recherche\, Université de Bordeaux – Invité\n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-maeva-andriantsoamberomanga/
CATEGORIES:IMN,Thesis
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