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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20250330T010000
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DTSTART;TZID=Europe/Paris:20250327T110000
DTEND;TZID=Europe/Paris:20250327T110000
DTSTAMP:20260422T103443
CREATED:20250304T121556Z
LAST-MODIFIED:20250313T111514Z
UID:181481-1743073200-1743073200@www.bordeaux-neurocampus.fr
SUMMARY:Conférence IBIO/RRI IMPACT - Michel Thiebaut de Schotten
DESCRIPTION:Venue: IBIO \nAlso on zoom :  <https://u-bordeaux-fr.zoom.us/j/83115534343?pwd=lF0rKLx94A9FOZcA2PTL1YIiW4EgSQ.1 \n\nMichel Thiebaut de Schotten\nTeam leader – IMN \nTitle\nA Human Brain Map of Mitochondrial Respiratory Capacity and Diversity \nAbstract\nMitochondrial oxidative phosphorylation (OxPhos) powers brain activity1\,2\, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders3\,4\, underscoring the need to define the brain’s molecular energetic landscape5–10. To bridge the cognitive neuroscience and cell biology scale gap\, we developed a physical voxelization approach to partition a frozen human coronal hemisphere section into 703 voxels comparable to neuroimaging resolution (3×3×3 mm). In each cortical and subcortical brain voxel\, we profiled mitochondrial phenotypes including OxPhos enzyme activities\, mitochondrial DNA and volume density\, and mitochondria-specific respiratory capacity. We show that the human brain contains a diversity of mitochondrial phenotypes driven by both topology and cell types. Compared to white matter\, grey matter contains >50% more mitochondria. We show that the more abundant grey matter mitochondria also are biochemically optimized for energy transformation\, particularly among recently evolved cortical brain regions. Scaling these data to the whole brain\, we created a backward linear regression model integrating several neuroimaging modalities11\, thereby generating a brain-wide map of mitochondrial distribution and specialization that predicts mitochondrial characteristics in an independent brain region of the same donor brain. This new approach and the resulting MitoBrainMap of mitochondrial phenotypes provide a foundation for exploring the molecular energetic landscape that enables normal brain functions\, relating it to neuroimaging data\, and defining the subcellular basis for regionalized brain processes relevant to neuropsychiatric and neurodegenerative disorders. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/conference-ibio-rri-impact-michel-thiebaut-de-schotten/
CATEGORIES:For scientists,home-event,IMN,Impromptu seminar
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DTSTART;TZID=Europe/Paris:20250327T190000
DTEND;TZID=Europe/Paris:20250327T190000
DTSTAMP:20260422T103443
CREATED:20250220T100653Z
LAST-MODIFIED:20250414T135745Z
UID:180966-1743102000-1743102000@www.bordeaux-neurocampus.fr
SUMMARY:Conférence : Que peut l’IA pour améliorer la santé mentale ?
DESCRIPTION:Lieu : Centre hospitalier Charles Perrens – Amphithéâtre\n121 rue de la Béchade\, Bordeaux \n\nOrganisée par le C.H. Charles Perrens. \nAvec :\n– Stéphane Mouchabac (APHP – Hôpital Saint Antoine\, Paris)\n– Thomas Bienvenu (Charles Perrens / Neurocentre Magendie)\n– David Mesdrahi (Charles Perrens / INCIA) \nEvénement complet : les inscriptions sont closes \n\nEvénement organisé dans le cadre de la Semaine du cerveau 2025 \n  \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/conference-que-peut-lia-pour-ameliorer-la-sante-mentale/
CATEGORIES:Events for all,IMN,pour tous homepage,Semaine du cerveau 2025
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