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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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DTSTART:20250330T010000
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DTSTART:20251026T010000
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DTSTART;TZID=Europe/Paris:20250314T090000
DTEND;TZID=Europe/Paris:20250314T171500
DTSTAMP:20260422T122842
CREATED:20241122T172301Z
LAST-MODIFIED:20250114T090958Z
UID:178060-1741942800-1741972500@www.bordeaux-neurocampus.fr
SUMMARY:Colloque étudiants de Neurobiologie des comportements
DESCRIPTION:Lieu : BBS \n\nColloque pour les étudiants en biologie. Entrée libre dans la limite des quelques places disponibles. \nProgramme\n9h Introduction par Muriel Darnaudery et Jean-Louis Guillou \n9h30-10h15 – Christelle Jozet Alves (Maîtresse de Conférences\, Université de Caen)\nLes pieuvres indisciplinées sont les plus fréquentes ! utilisation de stratégies multiples et individuellement variables dans une tâche de mémoire de type épisodique chez Octopus Vulgaris \n10h15-11h00 Arthur Leblois (Chargé de recherche CNRS\, IMN\, Bordeaux)\nMécanismes neuronaux de l’apprentissage du chant chez l’oiseau: de l’exploration vocale à la production stéréotypée \n16h00-16H30 – pause café \n11h30-12h15 – Aurélie Célérier (Maîtresse de Conférences\, Université de Montpellier\, Centre d’Ecologie Fonctionnel et Evolutive)\nLes cétacés ont-ils bon goût et du nez ? \n14H30-15H15 – Shauna Parkes (Chargée de recherche CNRS\, INCIA\, Bordeaux)\nValue-guided decision-making in rats and humans \n15H15-16H00 – Sébastien Parnaudeau (Chargé de recherche CNRS\, PARIS)\nEffet de la hiérarchie sociale sur la variabilité comportementale et la vulnérabilité aux psychopathologies \n16h00-16h30 – pause café \n16h30-17h15 – Véronique Deroche Gamonet (Directrice de recherche Inserm\, Neurocentre Magendie\, Bordeaux)\nComment savoir si mon rat est accro ?? \n
URL:https://www.bordeaux-neurocampus.fr/en/event/colloque-etudiants-de-neurobiologie-des-comportements/
CATEGORIES:For scientists,home-event,IINS,IMN,iNCIA,Magendie,Nutrineuro,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T093000
DTEND;TZID=Europe/Paris:20250314T093000
DTSTAMP:20260422T122842
CREATED:20250130T160625Z
LAST-MODIFIED:20250225T134949Z
UID:180181-1741944600-1741944600@www.bordeaux-neurocampus.fr
SUMMARY:Mini-symposium - Immune cells\, Inflammation and Brain disorders
DESCRIPTION:Venue: Centre Broca \nOrganized by Eric Boué-Grabot (IMN) \n\nSpeakers\n9:30 – Bart EGGEN – Professeur\, University Medical Center Groningen\, Groningen\, Pays-Bas\nTitle: Microglia in the diseased human CNS from an -omics perspective \n9:55 – Cécile DELARASSE – CR\, Inserm\, Institut de la Vision\, Paris\, France\nTitle : Macrophages in retinal diseases \n10:20 – Séverine BOILLÉE – DR\, Inserm\, Paris Brain Institute\, Paris\, France\nTitle : Implication of peripheral macrophages in ALS \n10:45 – Philippe SÉGUÉLA – Professeur\, McGill University\, Montréal\, Canada\nTitle : Blocking peripheral ASICs for the treatment of inflammatory pain. \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/mini-symposium/
CATEGORIES:For scientists,home-event,IMN,Symposium
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T140000
DTEND;TZID=Europe/Paris:20250314T140000
DTSTAMP:20260422T122842
CREATED:20241216T131809Z
LAST-MODIFIED:20250219T181629Z
UID:178903-1741960800-1741960800@www.bordeaux-neurocampus.fr
SUMMARY:Thesis defense - Sara Carracedo
DESCRIPTION:Venue: Centre Broca \n \nThesis defended in english \n\nSara Carracedo\nIMN\nThesis directed by Eric Boue-Grabot \nTitle\nNeuronal and microglial function of P2X4 receptor in Amyotrophic lateral sclerosis and its potential use as a biomarker \nAbstract\nAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive degeneration of motor neurons (MNs)\, driven by misfolded protein aggregation and neuroimmune dysregulation. P2X4 receptor\, an ATP-gated ion channel expressed in neurons and glial cells\, has emerged as a key player in ALS pathogenesis. Under normal conditions\, P2X4 is primarily internalized\, maintaining low surface expression. However\, in pathological states such as ALS\, P2X4 is increasingly localized to the cell surface. \nUsing double-transgenic SOD1 G93A (SOD1) mice expressing either an internalization-defective P2X4-mCherryIN knock-in or invalidated for the P2X4 gene\, it was reported that both the increase in surface P2X4 and its absence improved disease outcomes. These findings suggest complex cell-specific roles of P2X4 receptor\, which remains unexplored. Thus\, this study aims to investigate the distinct neuronal and microglial roles of the P2X4 receptor in ALS using triple-transgenic mice designed to selectively manipulate P2X4 expression in microglia/macrophages or neurons in the SOD1 mice model. \nOur results demonstrate that an increase in neuronal surface P2X4 accelerates ALS progression\, while its upregulation in microglia/macrophages slows disease progression. In microglia\, surface P2X4 mitigates immune overactivation in the spinal cord and reduces immune cell infiltration along MN axons in SOD1 mice. Consistent with this data\, cell-specific deletion of P2X4 had opposing effects on ALS progression: the absence of P2X4 in neurons was protective\, whereas its deletion in microglia/macrophages worsened disease outcomes. Altogether\, we found that neuronal and microglial P2X4 play dual and opposing roles in ALS pathophysiology. \nIn SOD1 mice\, elevated surface P2X4 expression was previously observed in peritoneal macrophages even before symptom onset. Translating this finding to humans\, we developed a flow cytometry-based method to measure the surface-to-total ratio of P2X4 in monocytes from peripheral blood samples. ALS patients\, particularly women\, exhibited significantly higher surface P2X4 levels in monocytes compared to patients with other neuromuscular diseases. This aberrant surface P2X4 expression was detected in both sporadic and familial forms of ALS\, regardless of whether the disease had a bulbar or lumbar onset\, underscoring the broad utility of P2X4 as a blood-based biomarker for ALS. \nIn conclusion\, our data reveal dual and opposing roles of neuronal and microglial P2X4 receptors in ALS progression and highlight its potential as both a therapeutic target and a diagnostic biomarker for ALS. \nKey words\n ALS\, P2X4\, Receptor trafficking\, Microglia\, Macrophages\, Immune response \nPublications\nCarracedo S\, Launay A\, Dechelle-Marquet PA\, Faivre E\, Delarasse C\, Blum D and Boué-Grabot E (2024) Purinergic-associated immune responses in neurodegenerative diseases (2024). Progress in Neurobiology. Vol 243\, 102693. \nGilabert D\, Duveau A\, Carracedo S\, Linck N\, Langla A\, Grutter T\, Muramatsu R\, Koch-Nolte F\, Fossat P\, Boué-Grabot E and Ulmann L (2023). Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice. iScience: S2589-0042(23)02187-9. \nBertin E\, Martinez A\, Fayoux A\, Carvalho K\, Carracedo S\, Fernagut P\, Koch-Nolte F\, Blum D\, Bertrand S and Boué- Grabot E (2022). Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice. Cellular and Molecular Life Sciences 79(8):431. \nJury\nSéverine BOILLEE  DR\, CNRS\, Bordeaux Rapportrice \nBart EGGEN Examinateur\, University Medical Center Groningen\, The Netherlands \nPhilippe SEGUELA Raporteur Pr. McGill University\, Canada \nCecile DELARASSE  DR\, CNRS\, Paris\,  Examinatrice \nAgnes NADJAR Président Rapporteur \nSandrine BERTRAND  DR\, CNRS\, Bordeaux  Invitée \nGwendal LEMASSON\, DR\, INSERM\, Bordeaux\, Invitée \nEric BOUE-GRABOT  DR\, CNRS\, Bordeaux  Directeur de thèse \n
URL:https://www.bordeaux-neurocampus.fr/en/event/thesis-defense-sara-carracedo/
CATEGORIES:IMN,Thesis
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250314T183000
DTEND;TZID=Europe/Paris:20250314T183000
DTSTAMP:20260422T122842
CREATED:20250212T182928Z
LAST-MODIFIED:20250414T135846Z
UID:180961-1741977000-1741977000@www.bordeaux-neurocampus.fr
SUMMARY:Conférence : "Des neurones aux algorithmes: quelle intelligence pour demain ?"
DESCRIPTION:Lieu : PJJ – 35 place Pey Berland\, Bordeaux \n\nL’intelligence artificielle bouleverse notre compréhension du monde et de nous-mêmes. Comment fonctionne-t-elle ? Qu’entendons-nous par « intelligence » artificielle ? Pouvons-nous imaginer que l’intelligence humaine soit un jour surpassée ? Accompagnés par quatre experts en IA et neurosciences computationnelles\, cette conférence vous propose une plongée au cœur des réseaux de neurones\, biologiques et artificiels\, pour mieux comprendre les enjeux et perspectives de l’IA. Entre avancées scientifiques\, limites actuelles et implications éthiques\, venez explorer avec nous les défis de l’intelligence de demain. \nAvec :\n– Cédric Brun (Univ. Bordeaux Montaigne\, IMN)\n– Xavier Hinault (Inria\, IMN)\,\n– Arthur Leblois (CNRS\, IMN)\,\n– Nicolas Rougier (Inria\, IMN) \nInscription\nhttps://framaforms.org/formulaire-dinscription-a-la-conference-des-neurones-aux-algorithmes-1740046425 \n\nOrganisé par \n \nAscoergo\, association des étudiants en sciences cognitives et ergonomie \n\nEvénement organisé dans le cadre de la Semaine du cerveau 2025 \n
URL:https://www.bordeaux-neurocampus.fr/en/event/conference-des-neurones-aux-algorithmes-quelle-intelligence-pour-demain/
CATEGORIES:Events for all,IMN,pour tous homepage,Semaine du cerveau 2025
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