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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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TZID:Europe/Paris
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TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20260329T010000
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DTSTART:20261025T010000
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20261119
DTEND;VALUE=DATE:20261209
DTSTAMP:20261109T111627
CREATED:20260303T224832Z
LAST-MODIFIED:20260316T142622Z
UID:195195-1795046400-1796774399@www.bordeaux-neurocampus.fr
SUMMARY:Cajal lectures - Neurobiology of Sleep
DESCRIPTION:Venue: CARF \n\nLectures are open to everyone. \nDetails about the course:\nhttps://cajal-training.org/on-site/neurobiology_sleep/ \n
URL:https://www.bordeaux-neurocampus.fr/en/event/cajal-lectures-neurobiology-of-sleep/
CATEGORIES:Cajal Lectures,For scientists,home-event
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261120T113000
DTEND;TZID=Europe/Paris:20261120T113000
DTSTAMP:20261109T111627
CREATED:20260604T132614Z
LAST-MODIFIED:20260605T113307Z
UID:198622-1795174200-1795174200@www.bordeaux-neurocampus.fr
SUMMARY:Friday seminar - Dmitry Lim
DESCRIPTION:Venue: Centre Broca \n\nPr Dmitry Lim\nAssociate Professor\,\nDepartment of Pharmaceutical Sciences\, Università del Piemonte Orientale\nNovara\, Italy\nhttps://research.uniupo.it/en/persons/dmitry-lim-11/\n \nInvited by Giulia Dematteis and Giovanni Marsicano (Neurocentre Magendie) \nTitle\nA chicken and the egg: ER-mitochondria interaction and protein homeostasis in Alzheimer’s disease and beyond. \nAbstract\nNeurodegenerative diseases (NDDs)\, including Alzheimer’s disease (AD)\, are characterised by early dysregulation of protein-synthetic and proteolytic mechanisms leading to accumulation of misfolded or aggregation-prone proteins. Protein dyshomeostasis in astroglial cells\, homeostatic cells in the CNS\, leads to loss of their neuroprotective functions\, predisposing neurons to dysfunction and degeneration. \nMitochondria-ER contact sites (MERCS) emerged as morpho-functional hubs coordinating core cellular functions\, including protein synthesis and degradation. Although growing body of reports associate disruption of MERCS with NDDs and AD pathogenesis\, promoting MERCS as therapeutic target\, their primary role in cell dysfunctions remain controversial. We reported that\, in astrocytes\, dysregulation of protein synthesis and degradation\, characteristic for AD astrocytes\, may be mimicked by artificial shortening of ER-mitochondrial distance to ~10nm. Contrarily\, stabilization of MERCS at near physiological distance of ~20nm in 3xTg-AD astrocytes\, rescued not only mitochondrial Ca2+ uptake\, but also protein homeostasis including normalization of autophagic flux and proteasomal activity. Strikingly\, AD-relevant pathological conversion of constitutive proteasome to immunoproteasome was also rescued. \nIn another pathological context\, we and others found that disruption of MERCS represent the earliest event of high-fat diet-induced obesity. Moreover\, reports suggest that stabilization MERCS at about 20nm in liver cells prevented a diet-induced obesity and insulin resistance in mice. Altogether\, our and other’s data suggest that MERCS alterations represent an earliest and causative event unleashing downstream disruption of protein homeosis. These results also prove that MERCS represent a druggable target for development of therapeutic strategies. \n
URL:https://www.bordeaux-neurocampus.fr/en/event/friday-seminar-dmitry-lim/
CATEGORIES:For scientists,home-event,Magendie,Seminars
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DTSTART;TZID=Europe/Paris:20261120T143000
DTEND;TZID=Europe/Paris:20261120T143000
DTSTAMP:20261109T111627
CREATED:20261106T100502Z
LAST-MODIFIED:20261106T123246Z
UID:208288-1795185000-1795185000@www.bordeaux-neurocampus.fr
SUMMARY:HDR defense - Céline Nicolas
DESCRIPTION:\n	\n		\n			Venue: BBS \n\n\n		\n	\n\n	\n		\n		\n			\n		\n	\n\n	\n		\n			Neural and behavioral substrates of drug relapse: sex and hormonal-specific modulation \nMy research focuses on understanding the behavioral and neurobiological mechanisms underlying drug addiction\, with a particular interest in relapse vulnerability. During my thesis\, I studied how environmental factors influence drug relapse vulnerability. In rats\, I identified\, specific long-lasting metabolic brain changes during cocaine abstinence in neurocircuits involved in reward\, motivation\, salience and stress. Moreover\, I demonstrated that the interactions with positive environmental stimuli during abstinence protects against drug relapse by modulating brain regions involved in stress-related behaviors. During my post-doctoral work\, I studied how internal biological factors\, such as sex and ovarian hormones could play a role in drug relapse vulnerability. I demonstrated that incubation of cocaine craving was higher in female than male rats\, an effect dependent on the estrous cycle. Additionally\, I identified a sexually dimorphic coding and causal role of the insular cortex in persistent alcohol drinking despite aversion in mice. My current research projects focus on identifying and understanding fundamental behavioral principles and the hormonal and neuronal circuit mechanisms involved in sex differences in drug addiction. \n  \nJury members: \nMarcello Solinas\, CNRS\, University of Poitiers (President) \nKatia Befort\, CNRS\, University of Strasbourg (Reviewer) \nCatherine Le Moine\, CNRS\, University of Bordeaux (Reviewer) \nVictor Mathis\, INSERM\, University of Strasbourg (Reviewer) \nMario Carta\, CNRS\, University of Bordeaux (Examinator) \nMuriel Koehl\, CNRS\, University of Bordeaux (Examinator) \n\n		\n	\n\n
URL:https://www.bordeaux-neurocampus.fr/en/event/hdr-defense-celine-nicolas/
CATEGORIES:HDR,home-event
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