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X-WR-CALNAME:Bordeaux Neurocampus
X-ORIGINAL-URL:https://www.bordeaux-neurocampus.fr/en/
X-WR-CALDESC:Events for Bordeaux Neurocampus
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DTSTART:20260329T010000
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DTSTART:20261025T010000
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DTSTART;TZID=Europe/Paris:20260522T113000
DTEND;TZID=Europe/Paris:20260522T113000
DTSTAMP:20260508T021144
CREATED:20250624T075616Z
LAST-MODIFIED:20260507T144715Z
UID:185507-1779449400-1779449400@www.bordeaux-neurocampus.fr
SUMMARY:PhD Seminar - Manuel Valero
DESCRIPTION:Venue: Centre Broca \n\nDr. Manuel Valero \nIMIM\, Barcelona\, Spain \nInvited by Julia Welte (Neurocentre Magendie) \nTitle\nCell-Type-Specific Inhibitory Mechanisms of Memory Reactivation \nAbstract\nMemories are thought to be consolidated through the reactivation of neuronal assemblies during high-frequency hippocampal events\, including sharp-wave ripples (SPW-Rs) and fast gamma oscillations. However\, the circuit mechanisms governing the formation and stabilization of these assemblies remain poorly understood. \nUsing silicon probes integrated with miniaturized LEDs\, we developed an approach to generate synthetic neuronal assemblies in vivo by selectively coactivating groups of CA1 pyramidal neurons in behaving mice. This approach allowed us to dissect the mechanisms underlying assembly formation in the hippocampus. \nOur results show that only high-frequency coactivation patterns induce persistent assembly formation and memory-reactivation-like dynamics\, despite other stimulation protocols producing similar levels of excitation. High-frequency stimulation uniquely recruits facilitating inhibitory responses mediated by specific interneuron populations\, including somatostatin and subsets of parvalbumin interneurons. The strength of inhibitory recruitment predicts the stabilization of induced assemblies and selectively suppresses competing activity patterns during subsequent sleep. \nFinally\, we present evidence suggesting that similar inhibitory mechanisms operate during naturally occurring learning-related assembly formation and memory reactivation\, supporting a broader role for inhibitory plasticity in organizing hippocampal population dynamics during memory consolidation. \nKey publications\nValero M†*\, Abad-Perez P†\, Gallardo A\, Picco M\, García-Hernandez R\, Brotons J\, Martínez-Félix A\, Machold R\, Rudy B\, Buzsáki G*.\nCooperative actions of interneuron families support the hippocampal spatial code.\nScience. 389\, 6764 (2025). \nValero M*\, Zutshi I\, Yoon E\, Buzsáki G*.\nProbing subthreshold dynamics of hippocampal neurons by pulsed optogenetics.\nScience. 375 (6580)\, 570-574 (2022). \nValero M\, Navas-Olive A\, Menendez de la Prida L\, Buzsáki G.\nInhibitory conductance controls place field dynamics in the hippocampus.\nCell Reports. 40 (8)\, 111232 (2022). \nMeet the speaker!\nYou are a research staff ? Write to Julia Goncalves who will organize the schedule. \nYou are a PhD student? You can register to share some pizza after the talk. Registration opens 3 weeks before. \n\nPhD seminars are organized by the NBA\, Bordeaux Neurocampus\, and the Bordeaux Neurocampus Graduate Program.  \n \n
URL:https://www.bordeaux-neurocampus.fr/en/event/phd-seminar-manuel-valero/
CATEGORIES:For scientists,home-event,Magendie,Monthly conferences
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DTSTART;TZID=Europe/Paris:20260522T140000
DTEND;TZID=Europe/Paris:20260522T140000
DTSTAMP:20260508T021145
CREATED:20260121T131125Z
LAST-MODIFIED:20260324T092533Z
UID:191859-1779458400-1779458400@www.bordeaux-neurocampus.fr
SUMMARY:Seminar - Vincent Breton-Provencher
DESCRIPTION:Venue: Centre Broca \n\nVincent Breton-Provencher\nhttps://vbplab.com/ \nInvited by Etienne Coutureau (INCIA) \n
URL:https://www.bordeaux-neurocampus.fr/en/event/seminar-vincent-breton-provencher/
CATEGORIES:For scientists,home-event,Seminars
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